Mediators of Inflammation

Mediators of Gut Mucosal Immunity and Inflammation


Status
Published

1Department of Immunology, School of Medicine, Bulent Ecevit University, Zonguldak, Turkey

2Department of Immunology, School of Medicine, Uludag University, Bursa, Turkey

3Department of Genetics and Cell-Biology, Maastricht University Medical Centre, Maastricht, The Netherlands


Mediators of Gut Mucosal Immunity and Inflammation

Description

The gastrointestinal tract is continuously exposed to foreign antigens such as derived from food and microbiota of gut. Gut flora is an important entity of human body that plays crucial role in healthy immune system and various immunological disorders. Exploration of interactions between gut flora and immune system is an important area of current investigations.

The first view of the mucosal immune systems is a single-layer epithelium covered by mucus and antimicrobial products and fortified by both innate and adaptive components of host defense. The migration of immune cells from mucosal inductive to effector tissues via the lymphatic system is the cellular basis for the immune response in the gastrointestinal system.

Cytokines and chemokines are an integral component of the adaptive and innate immune response in the gastrointestinal system. Cytokines are involved in a variety of immunological, inflammatory and infectious diseases. Chemokines are a family of small cytokines or proteins secreted by numerous cells. The major role of chemokines is to guide the migration of particular cells. The mediators of gut mucosal immunity and inflammation are not limited to chemokines and cytokines. There are many inflammatory and anti-inflammatory molecules derived from gut mucosal endothelial cells and leucocytes.

We invite researchers to contribute to this special issue in the form of original research articles or reviews that will further strengthen the efforts to understand the cellular and molecular mechanisms of mediators in gut immunity and inflammation. Also, we are waiting for clinical studies about our potential topics. Potential topics include, but are not limited to:

  • The importance of cytokines and chemokines in intestinal immune system and gut microbiota
  • Relationship between cytokines, chemokines, and gut microbiota in gastrointestinal inflammation
  • The immunomodulatory properties of commensal bacteria in the gut
  • Host cell cytokine and chemokine responses to distinct commensal-associated molecular patterns of probiotic strains
  • Role of gut microbiota in gastrointestinal and immunological diseases
  • Gut microbiota as an intervention target in metabolic function and obesity

Before submission authors should carefully read the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/mi/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System on http://mts.hindawi.com/submit/journals/mi/mgmi/ according to the following schedule:


Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 579830
  • - Research Article

The Impact of ATRA on Shaping Human Myeloid Cell Responses to Epithelial Cell-Derived Stimuli and on T-Lymphocyte Polarization

Arunima Chatterjee | Péter Gogolak | ... | Éva Rajnavölgyi
  • Special Issue
  • - Volume 2015
  • - Article ID 326032
  • - Review Article

Gut Inflammation and Immunity: What Is the Role of the Human Gut Virome?

Alfredo Focà | Maria Carla Liberto | ... | Grazia Pavia
  • Special Issue
  • - Volume 2015
  • - Article ID 605071
  • - Research Article

Moderate Exercise Training Attenuates the Severity of Experimental Rodent Colitis: The Importance of Crosstalk between Adipose Tissue and Skeletal Muscles

Jan Bilski | Agnieszka I. Mazur-Bialy | ... | Tomasz Brzozowski
  • Special Issue
  • - Volume 2014
  • - Article ID 879843
  • - Research Article

An In Vitro Model to Evaluate the Impact of the Soluble Factors from the Colonic Mucosa of Collagenous Colitis Patients on T Cells: Enhanced Production of IL-17A and IL-10 from Peripheral CD4+ T Cells

Ashok Kumar Kumawat | Nils Nyhlin | ... | Elisabeth Hultgren Hörnquist
  • Special Issue
  • - Volume 2014
  • - Article ID 852378
  • - Research Article

Tumor Necrosis Factor Induces Developmental Stage-Dependent Structural Changes in the Immature Small Intestine

Kathryn S. Brown | Huiyu Gong | ... | Steven J. McElroy
  • Special Issue
  • - Volume 2014
  • - Article ID 136329
  • - Research Article

The Possible Role of the Novel Cytokines IL-35 and IL-37 in Inflammatory Bowel Disease

Yanmei Li | Yanan Wang | ... | Xuefeng Lu
  • Special Issue
  • - Volume 2014
  • - Article ID 901530
  • - Research Article

Intestinal Mucosal Barrier Is Injured by BMP2/4 via Activation of NF-B Signals after Ischemic Reperfusion

Kang Chen | Wei Xie | ... | Chaojun Zhang
  • Special Issue
  • - Volume 2014
  • - Article ID 235460
  • - Review Article

An Overview of the Role of Innate Lymphoid Cells in Gut Infections and Inflammation

Silvia Sedda | Irene Marafini | ... | Giovanni Monteleone
  • Special Issue
  • - Volume 2014
  • - Article ID 837107
  • - Research Article

Glutamine Supplementation Attenuates Expressions of Adhesion Molecules and Chemokine Receptors on T Cells in a Murine Model of Acute Colitis

Yu-Chen Hou | Jin-Ming Wu | ... | Ming-Tsan Lin
  • Special Issue
  • - Volume 2014
  • - Article ID 348959
  • - Clinical Study

Effect of Probiotic (VSL#3) and Omega-3 on Lipid Profile, Insulin Sensitivity, Inflammatory Markers, and Gut Colonization in Overweight Adults: A Randomized, Controlled Trial

Hemalatha Rajkumar | Naseha Mahmood | ... | Shiva Prakash Myakala
Mediators of Inflammation
 Journal metrics
See full report
Acceptance rate13%
Submission to final decision140 days
Acceptance to publication24 days
CiteScore7.700
Journal Citation Indicator0.570
Impact Factor4.6
 Submit Evaluate your manuscript with the free Manuscript Language Checker

We have begun to integrate the 200+ Hindawi journals into Wiley’s journal portfolio. You can find out more about how this benefits our journal communities on our FAQ.