Mediators of Inflammation

Immunology and Infection by Protozoan Parasites


Status
Published

1University of São Paulo, São Paulo, SP, Brazil

2INSERM, Paris, France

3Universidade Federal de Säo Paulo-Escola Paulista de Medicina, Brazil

4Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil


Immunology and Infection by Protozoan Parasites

Description

Protozoan infection is the cause of diseases of high morbidity and mortality, like malaria, leishmaniasis, African trypanosomiasis, Chagas disease, and toxoplasmosis. Most are non-self-limiting chronic infections and neglected diseases; emergent antimicrobial-resistant strains pose a substantial problem; for many of them, treatment is either highly toxic or has limited effectiveness. Vaccine development is still a formidable task and there is no licensed vaccine for human protozoan infection. The key to control protozoan infection is the understanding of the host immune response to protozoan parasites, which will guide the development of effective vaccines and immunotherapeutic agents.

We invite authors to submit original research papers that seek to define the interaction between protozoan parasites and their products and the host immune system. Unsolicited review papers will also be analyzed. We are interested in articles that explore aspects of immunity against protozoan infection in humans, animal models, and ex vivo/in vitro systems. Potential topics include, but are not limited to:

  • Elucidating the role of host factors in the development of antiprotozoal innate and adaptative immunity
  • Elucidating the role of protozoal pathogen factors modulating mediators of inflammation in the outcome of infection
  • Identification of mechanisms employed by protozoan pathogens to escape the immune response
  • Identification of new antigenic targets of the human response to protozoan pathogens
  • New biomarkers that help identify and follow up protozoan infection, protective or pathogenic immune response, and clinical outcomes of protozoan infection
  • New cellular and animal model in the study of host-protozoan interactions and their corresponding immune responses
  • Pathogen or host genetic variables that affect the outcome of infection or its corresponding immune response
  • Systems biology approaches to study protozoan infection and its immune response
  • Development and testing of novel antiprotozoal vaccines
  • Development of immunotherapeutic strategies to treat protozoal infection
  • Clinical trials of novel immunotherapeutic agents to treat protozoal infection
  • Drug-immunotherapy combinations to treat protozoal infection

Before submission authors should carefully read the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/mi/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/mi/iai/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 504951
  • - Editorial

Immunology and Infection by Protozoan Parasites

Edecio Cunha-Neto | Christophe Chevillard | ... | Marcelo T. Bozza
  • Special Issue
  • - Volume 2015
  • - Article ID 595829
  • - Research Article

Human Leucocyte Antigen-G (HLA-G) and Its Murine Functional Homolog Qa2 in the Trypanosoma cruzi Infection

Fabrício C. Dias | Celso T. Mendes-Junior | ... | Eduardo A. Donadi
  • Special Issue
  • - Volume 2014
  • - Article ID 910621
  • - Research Article

Biomarker Analysis Revealed Distinct Profiles of Innate and Adaptive Immunity in Infants with Ocular Lesions of Congenital Toxoplasmosis

Anderson Silva Machado | Ana Carolina Aguiar Vasconcelos Carneiro | ... | UFMG Congenital Toxoplasmosis Brazilian Group —UFMG-CTBG
  • Special Issue
  • - Volume 2014
  • - Article ID 857245
  • - Research Article

Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil

Juan Camilo Sánchez-Arcila | Daiana de Souza Perce-da-Silva | ... | Joseli Oliveira-Ferreira
  • Special Issue
  • - Volume 2014
  • - Article ID 143450
  • - Research Article

Ecotin-Like ISP of L. major Promastigotes Fine-Tunes Macrophage Phagocytosis by Limiting the Pericellular Release of Bradykinin from Surface-Bound Kininogens: A Survival Strategy Based on the Silencing of Proinflammatory G-Protein Coupled Kinin B2 and B1 Receptors

Erik Svensjö | Larissa Nogueira de Almeida | ... | Julio Scharfstein
  • Special Issue
  • - Volume 2014
  • - Article ID 475919
  • - Research Article

Insulin-Like Growth Factor-I Induces Arginase Activity in Leishmania amazonensis Amastigote-Infected Macrophages through a Cytokine-Independent Mechanism

Celia Maria Vieira Vendrame | Marcia Dias Teixeira Carvalho | ... | Hiro Goto
  • Special Issue
  • - Volume 2014
  • - Article ID 902038
  • - Review Article

Trypanosoma cruzi Infection and Host Lipid Metabolism

Qianqian Miao | Momar Ndao
  • Special Issue
  • - Volume 2014
  • - Article ID 872464
  • - Research Article

Predictive Criteria to Study the Pathogenesis of Malaria-Associated ALI/ARDS in Mice

Luana S. Ortolan | Michelle K. Sercundes | ... | Sabrina Epiphanio
  • Special Issue
  • - Volume 2014
  • - Article ID 230129
  • - Research Article

Lipoprotein Lipase and PPAR Alpha Gene Polymorphisms, Increased Very-Low-Density Lipoprotein Levels, and Decreased High-Density Lipoprotein Levels as Risk Markers for the Development of Visceral Leishmaniasis by Leishmania infantum

Márcia Dias Teixeira Carvalho | Diego Peres Alonso | ... | Hiro Goto
  • Special Issue
  • - Volume 2014
  • - Article ID 475946
  • - Research Article

Effects of Cholinergic Stimulation with Pyridostigmine Bromide on Chronic Chagasic Cardiomyopathic Mice

Marília Beatriz de Cuba | Marcus Paulo Ribeiro Machado | ... | Valdo Jose Dias da Silva
Mediators of Inflammation
 Journal metrics
Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.000
Impact Factor3.758
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