Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most highly prescribed drugs in the world. Their analgesic, anti-inflammatory, and antipyretic actions may be beneficial; however, they are associated with severe side effects including gastrointestinal injury and peptic ulceration. Though several approaches for limiting these side effects have been adopted, like the use of COX-2 specific drugs, comedication of acid suppressants like proton pump inhibitors and prostaglandin analogs, these alternatives have limitations in terms of efficacy and side effects. In this paper, the mechanism of action of NSAIDs and their critical gastrointestinal complications have been reviewed. This paper also provides the information on different preventive measures prescribed to minimize such adverse effects and analyses the new suggested strategies for development of novel drugs to maintain the anti-inflammatory functions of NSAIDs along with effective gastrointestinal protection.

Mau Sinha

Lovely Gautam

Prakash Kumar Shukla

Punit Kaur

Sujata Sharma

Tej P. Singh

Current Perspectives in NSAID-Induced Gastropathy

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Mediators of Inflammation publishes papers on all types of inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules

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Chief Editor, Professor Agrawal, is an Assistant Clinical Professor of the Division of Basic and Clinical Immunology. Dr. Agrawal's research focuses on the dendritic cells of the immune system in the context of aging and autoimmunity.

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Mediators of Inflammation publishes papers on all types of inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules

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Mediators of Inflammation | Hindawi

Mediators of Inflammation

This Issue is now open for submissions.
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E. Arranz

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Mediators of Inflammation and Immune Responses in the Human Gastrointestinal Tract

Mediators of Inflammation

Mediators of Inflammation and Immune Responses in the Human Gastrointestinal Tract

Mediators of Inflammation and Immune Responses in the Human Gastrointestinal Tract

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Current Perspectives in NSAID-Induced Gastropathy