Mediators of Inflammation

Innate Immune and Inflammatory Responses to Respiratory Viruses


Publishing date
01 Feb 2019
Status
Published
Submission deadline
21 Sep 2018

Lead Editor

1Oklahoma State University, Oklahoma City, USA

2Guangzhou Medical University, Guangzhou, China

3University of Alabama, Tuscaloosa, USA


Innate Immune and Inflammatory Responses to Respiratory Viruses

Description

Respiratory viruses (RVs), including but not limited to influenza virus, respiratory syncytial virus (RSV), coronavirus, rhinovirus, parainfluenza virus, adenovirus, and human metapneumovirus, can lead to severe diseases including bronchiolitis and pneumonia, or/and to exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Given that vaccines are not available for RVs other than influenza virus, there is a critical need for development of effective therapies limiting the severity of inflammation caused by RV infection.

Lung airway epithelial cells and mucosal immune cells are the primary cells for RVs. Following viral infection, these cells generate a range of mediators, including type I interferons and proinflammatory cytokines and chemokines, which not only have pivotal roles in virus control but also determine the development of inflammation and disease. Thus, elucidation of the underlying mechanisms of host innate and inflammatory response to RVs will provide insights for developing novel therapeutic strategies to inhibit viral infection and prevent aberrant inflammation.

We cordially invite researchers to contribute original research articles as well as review articles in respiratory viruses-elicited innate and inflammatory responses. This calls for improved understanding of the pathogenesis of RVs and the consequences of host innate and inflammatory responses. This special issue will cover basic, translational, and clinical research addressing RV-related infectious diseases and inflammatory diseases.

Potential topics include but are not limited to the following:

  • RV-elicited or RV-exacerbated respiratory diseases, including, but not limited to, influenza, RSV, asthma, common cold, croup, bronchitis, pneumonia, COPD, cystic fibrosis, and idiopathic pulmonary fibrosis
  • Molecular mechanisms by which RVs induce innate and inflammatory responses
  • Common denominators between different RVs and the immune response towards them
  • Pathogenesis and interaction of RVs and respiratory bacteria
  • RNA-seq or cDNA arrays analysis of inflammatory gene expression caused by RVs
  • Translational study and clinical therapeutics for RVs and inflammation
  • Meta-analysis of the innate immune and inflammation caused by RVs

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 3146065
  • - Editorial

Innate Immune and Inflammatory Responses to Respiratory Viruses

Shitao Li | Bishi Fu | Chetan D. Meshram
  • Special Issue
  • - Volume 2019
  • - Article ID 7072917
  • - Research Article

The Differential Expression of Mitochondrial Function-Associated Proteins and Antioxidant Enzymes during Bovine Herpesvirus 1 Infection: A Potential Mechanism for Virus Infection-Induced Oxidative Mitochondrial Dysfunction

Xiaotian Fu | Xinyi Jiang | ... | Gaiping Zhang
  • Special Issue
  • - Volume 2019
  • - Article ID 3231696
  • - Research Article

CD4+ TSCMs in the Bone Marrow Assist in Maturation of Antibodies against Influenza in Mice

Kang Wu | Fei Wang | ... | Xuefeng Li
  • Special Issue
  • - Volume 2019
  • - Article ID 5160694
  • - Research Article

The Role of Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis

Dong Weng | Xian-Qiu Chen | ... | Hui-Ping Li
  • Special Issue
  • - Volume 2018
  • - Article ID 6808934
  • - Research Article

RIG-I Signaling via MAVS Is Dispensable for Survival in Lethal Influenza Infection In Vivo

Wenxin Wu | Xiaoqiu Wang | ... | Jordan P. Metcalf
  • Special Issue
  • - Volume 2018
  • - Article ID 2320640
  • - Research Article

MicroRNA Expression Profile of Whole Blood Is Altered in Adenovirus-Infected Pneumonia Children

Feng Huang | Junsong Zhang | ... | Gen Lu
Mediators of Inflammation
 Journal metrics
Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.000
Impact Factor3.758
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