Inflammatory Mediators in Obesity
1Virginia Commonwealth University, Richmond, USA
2University of Houston, Texas, USA
3Rayalaseema University, Andhra Pradesh, India
Inflammatory Mediators in Obesity
Description
Obesity that is linked to metabolic syndrome and systemic inflammation has reached an epidemic level globally and has emerged as a serious public health challenge. Obesity-induced inflammation is a chronic low grade inflammatory state orchestrated by the metabolic cells in response to excessive nutrients. Inflammation occurs in several tissues such as adipose tissue, liver, brain, skeletal muscle, pancreas, and gut and is considered as one of the hallmarks of metabolic diseases. The inflammatory responses triggered by obesity are marked by increased production of proinflammatory cytokines and acute phase proteins, activation of leukocytes, and organelle dysfunction of the metabolic cells. Sustained inflammation has been implicated as a strong risk factor in the pathogenesis of obesity-related insulin resistance, cardiovascular diseases, type 2 diabetes, and cancer. Thus, multiple signaling networks are activated contributing to inflammatory signaling that affects metabolic homeostasis underscoring a critical need for the development of effective therapeutic interventions targeting inflammatory pathways in obesity.
This special issue is focused on shedding light on the potential triggers of inflammation in obesity and its related pathogenesis of chronic diseases. We invite researchers to submit original research or review articles related to basic, translational, or clinical research stimulating ideas that would open new avenues of investigations in this field.
Potential topics include but are not limited to the following:
- Genesis of inflammation in obesity
- Cellular mediators of inflammation in obesity
- Oxidative stress and inflammation in obesity
- Role of inflammation in obesity-associated diseases
- Significance of inflammatory pathways as a potential therapeutic target in obesity