Mediators of Inflammation

Inflammatory Mediators in Obesity


Publishing date
01 Jun 2019
Status
Published
Submission deadline
08 Feb 2019

Lead Editor

1Virginia Commonwealth University, Richmond, USA

2University of Houston, Texas, USA

3Rayalaseema University, Andhra Pradesh, India


Inflammatory Mediators in Obesity

Description

Obesity that is linked to metabolic syndrome and systemic inflammation has reached an epidemic level globally and has emerged as a serious public health challenge. Obesity-induced inflammation is a chronic low grade inflammatory state orchestrated by the metabolic cells in response to excessive nutrients. Inflammation occurs in several tissues such as adipose tissue, liver, brain, skeletal muscle, pancreas, and gut and is considered as one of the hallmarks of metabolic diseases. The inflammatory responses triggered by obesity are marked by increased production of proinflammatory cytokines and acute phase proteins, activation of leukocytes, and organelle dysfunction of the metabolic cells. Sustained inflammation has been implicated as a strong risk factor in the pathogenesis of obesity-related insulin resistance, cardiovascular diseases, type 2 diabetes, and cancer. Thus, multiple signaling networks are activated contributing to inflammatory signaling that affects metabolic homeostasis underscoring a critical need for the development of effective therapeutic interventions targeting inflammatory pathways in obesity.

This special issue is focused on shedding light on the potential triggers of inflammation in obesity and its related pathogenesis of chronic diseases. We invite researchers to submit original research or review articles related to basic, translational, or clinical research stimulating ideas that would open new avenues of investigations in this field.

Potential topics include but are not limited to the following:

  • Genesis of inflammation in obesity
  • Cellular mediators of inflammation in obesity
  • Oxidative stress and inflammation in obesity
  • Role of inflammation in obesity-associated diseases
  • Significance of inflammatory pathways as a potential therapeutic target in obesity

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 9481819
  • - Editorial

Inflammatory Mediators in Obesity

Divya P. Kumar | Saisudha Koka | ... | Senthilkumar Rajagopal
  • Special Issue
  • - Volume 2019
  • - Article ID 6321427
  • - Clinical Study

Circulating ANGPTL8 Is Associated with the Presence of Metabolic Syndrome and Insulin Resistance in Polycystic Ovary Syndrome Young Women

Danlan Pu | Ling Li | ... | Qinan Wu
  • Special Issue
  • - Volume 2019
  • - Article ID 2872607
  • - Review Article

Prognostic Role of Elevated Myeloperoxidase in Patients with Acute Coronary Syndrome: A Systemic Review and Meta-Analysis

Andrew R. Kolodziej | Mohamed Abo-Aly | ... | Ahmed Abdel-Latif
  • Special Issue
  • - Volume 2019
  • - Article ID 7353420
  • - Review Article

Biomarkers of Inflammation in Obesity-Psoriatic Patients

Carmen Rodríguez-Cerdeira | Mónica Cordeiro-Rodríguez | ... | José Luís González-Cespón
  • Special Issue
  • - Volume 2019
  • - Article ID 3172647
  • - Research Article

CD36-Mediated Lipid Accumulation and Activation of NLRP3 Inflammasome Lead to Podocyte Injury in Obesity-Related Glomerulopathy

Jing Zhao | Hong-liang Rui | ... | Hong Cheng
  • Special Issue
  • - Volume 2019
  • - Article ID 4165260
  • - Research Article

Impact of Intensive Lifestyle Modification on Levels of Adipokines and Inflammatory Biomarkers in Metabolically Healthy Obese Women

Ricardo Gomez-Huelgas | Josefina Ruiz-Nava | ... | M. Rosa Bernal-Lopez
  • Special Issue
  • - Volume 2019
  • - Article ID 6737318
  • - Research Article

Association between Irisin, hs-CRP, and Metabolic Status in Children and Adolescents with Type 2 Diabetes Mellitus

Leticia Elizondo-Montemayor | Adrian M. Gonzalez-Gil | ... | Gerardo Garcia-Rivas
  • Special Issue
  • - Volume 2019
  • - Article ID 1491083
  • - Research Article

Circulating Monocyte and Lymphocyte Populations in Healthy First-Degree Relatives of Type 2 Diabetic Patients at Fasting and during Short-Term Hyperinsulinemia

Michaela Šiklová | Eva Krauzová | ... | Lenka Rossmeislová
  • Special Issue
  • - Volume 2019
  • - Article ID 2712376
  • - Research Article

Soluble Receptor for Advanced Glycation End Products: A Protective Molecule against Intramyocardial Lipid Accumulation in Obese Zucker Rats?

Elena Dozio | Elena Vianello | ... | Massimiliano M. Corsi Romanelli
  • Special Issue
  • - Volume 2019
  • - Article ID 1648614
  • - Research Article

High-Fat Diet Alters Immunogenic Properties of Circulating and Adipose Tissue-Associated Myeloid-Derived CD45+DDR2+ Cells

Sara J. Sidles | Ying Xiong | ... | Amanda C. LaRue
Mediators of Inflammation
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Acceptance rate14%
Submission to final decision136 days
Acceptance to publication27 days
CiteScore7.700
Journal Citation Indicator0.570
Impact Factor4.6
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