Mediators of Inflammation

Modulation of Toll-like Receptor Signalling as a New Therapeutic Principle


Publishing date
01 Aug 2010
Status
Published
Submission deadline
02 Feb 2010

1Department of Pneumology, University Hospital of Bern, 3010 Bern, Switzerland

2Department of Dermatology and Allergy, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany

3Department of Biochemistry, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK

4School of Biochemistry and Immunology, Trinity College Dublin, Ireland

5Opsona Therapeutics Ltd., The Trinity Centre for Health Sciences, Institute of Molecular Medicine, St. James's Hospital, Dublin, Ireland

6Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, 81675 Munich, Germany


Modulation of Toll-like Receptor Signalling as a New Therapeutic Principle

Description

The past 10 years in immunology were characterized by breakthrough progress in the field of innate immunity, especially by the definition of the interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) superfamily. Toll-like receptors are pattern recognition receptors that play a predominant role for innate immunity and inflammation. After much insights into the basic signalling events, the next step will be to unravel the therapeutic potential of the modulation of different TLR/IL1R-pathways. These pathways are involved in many different pathologies, and the therapeutic interference could have a substantial clinical benefit in a variety of diseases, ranging from allergy, over atherosclerosis, to cancer.

We invite authors to present original research articles as well as review articles that will stimulate the continuing efforts in defining the role of innate immunity signalling pathways in clinical applications. We are particularly interested in manuscripts that report the clinical applications of approved or investigational TLR-modulating therapy in various fields of medicine (cardiovascular, oncology, dermatology, pneumology, etc.) with emphasis on efficacy, toxicity, response assessment, prognostic factors, and predictive markers. Reviews that summarize the results of basic research on Toll-like receptors and innate immunity receptors, or those receptors as targets in clinical trials and their future implications on treatment practice, are particularly welcome. Potential topics include but are not limited to:

  • Clinical implications of innate immune signalling
  • Therapeutical exploitation of signalling
  • Clinical trials on innate immune signalling

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/mi/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2010
  • - Article ID 705612
  • - Editorial

Modulation of Toll-Like Receptor Signalling as a New Therapeutic Principle

Philipp M. Lepper | Martha Triantafilou | ... | Kathy Triantafilou
  • Special Issue
  • - Volume 2010
  • - Article ID 781235
  • - Review Article

Toll-Like Receptor Signaling Pathways—Therapeutic Opportunities

Jiankun Zhu | Chandra Mohan
  • Special Issue
  • - Volume 2010
  • - Article ID 652098
  • - Research Article

The p110 and p110 Isoforms of Class I Phosphatidylinositol 3-Kinase Are Involved in Toll-Like Receptor 5 Signaling in Epithelial Cells

Sabine M. Ivison | Mohammed A. S. Khan | ... | Theodore S. Steiner
  • Special Issue
  • - Volume 2010
  • - Article ID 498980
  • - Review Article

Targeting Toll-Like Receptors for Treatment of SLE

Christopher G. Horton | Zi-jian Pan | A. Darise Farris
  • Special Issue
  • - Volume 2010
  • - Article ID 581837
  • - Review Article

Toll-Like Receptors, Tissue Injury, and Tumourigenesis

Savvas Ioannou | Michael Voulgarelis
  • Special Issue
  • - Volume 2010
  • - Article ID 437246
  • - Review Article

Toll-Like Receptors: Role in Dermatological Disease

Aswin Hari | Tracy L. Flach | ... | P. Régine Mydlarski
  • Special Issue
  • - Volume 2010
  • - Article ID 748218
  • - Research Article

Expression of TLR4-MyD88 and NF- B in the Iris during Endotoxin-Induced Uveitis

Shang Li | Hong Lu | ... | Jing Wang
  • Special Issue
  • - Volume 2010
  • - Article ID 373878
  • - Review Article

Biliary Innate Immunity: Function and Modulation

Kenichi Harada | Yasuni Nakanuma
  • Special Issue
  • - Volume 2010
  • - Article ID 497987
  • - Review Article

Toll-Like Receptors Expression and Signaling in Glia Cells in Neuro-Amyloidogenic Diseases: Towards Future Therapeutic Application

Dorit Trudler | Dorit Farfara | Dan Frenkel
  • Special Issue
  • - Volume 2010
  • - Article ID 916425
  • - Review Article

Association of Toll-Like Receptor Signaling and Reactive Oxygen Species: A Potential Therapeutic Target for Posttrauma Acute Lung Injury

Meng Xiang | Janet Fan | Jie Fan
Mediators of Inflammation
 Journal metrics
Acceptance rate41%
Submission to final decision77 days
Acceptance to publication36 days
CiteScore3.570
Impact Factor3.545
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