Mediators of Inflammation

Modulation of Toll-like Receptor Signalling as a New Therapeutic Principle


Publishing date
01 Aug 2010
Status
Published
Submission deadline
02 Feb 2010

1Department of Pneumology, University Hospital of Bern, 3010 Bern, Switzerland

2Department of Dermatology and Allergy, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany

3Department of Biochemistry, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK

4School of Biochemistry and Immunology, Trinity College Dublin, Ireland

5Opsona Therapeutics Ltd., The Trinity Centre for Health Sciences, Institute of Molecular Medicine, St. James's Hospital, Dublin, Ireland

6Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, 81675 Munich, Germany


Modulation of Toll-like Receptor Signalling as a New Therapeutic Principle

Description

The past 10 years in immunology were characterized by breakthrough progress in the field of innate immunity, especially by the definition of the interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) superfamily. Toll-like receptors are pattern recognition receptors that play a predominant role for innate immunity and inflammation. After much insights into the basic signalling events, the next step will be to unravel the therapeutic potential of the modulation of different TLR/IL1R-pathways. These pathways are involved in many different pathologies, and the therapeutic interference could have a substantial clinical benefit in a variety of diseases, ranging from allergy, over atherosclerosis, to cancer.

We invite authors to present original research articles as well as review articles that will stimulate the continuing efforts in defining the role of innate immunity signalling pathways in clinical applications. We are particularly interested in manuscripts that report the clinical applications of approved or investigational TLR-modulating therapy in various fields of medicine (cardiovascular, oncology, dermatology, pneumology, etc.) with emphasis on efficacy, toxicity, response assessment, prognostic factors, and predictive markers. Reviews that summarize the results of basic research on Toll-like receptors and innate immunity receptors, or those receptors as targets in clinical trials and their future implications on treatment practice, are particularly welcome. Potential topics include but are not limited to:

  • Clinical implications of innate immune signalling
  • Therapeutical exploitation of signalling
  • Clinical trials on innate immune signalling

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/mi/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2010
  • - Article ID 672395
  • - Review Article

DAMPening Inflammation by Modulating TLR Signalling

A. M. Piccinini | K. S. Midwood
  • Special Issue
  • - Volume 2010
  • - Article ID 475139
  • - Research Article

Interleukin-6 Contributes to Age-Related Alteration of Cytokine Production by Macrophages

Christian R. Gomez | John Karavitis | ... | Elizabeth J. Kovacs
  • Special Issue
  • - Volume 2010
  • - Article ID 567351
  • - Review Article

Type I IL-1 Receptor (IL-1RI) as Potential New Therapeutic Target for Bronchial Asthma

Jyh-Hong Lee | Li-Chieh Wang | ... | Bor-Luen Chiang
  • Special Issue
  • - Volume 2010
  • - Article ID 393946
  • - Review Article

The Expression and Functions of Toll-Like Receptors in Atherosclerosis

Jennifer E. Cole | Ektoras Georgiou | Claudia Monaco
  • Special Issue
  • - Volume 2010
  • - Article ID 536478
  • - Review Article

Modulation of Toll-Like Receptor Activity by Leukocyte Ig-Like Receptors and Their Effects during Bacterial Infection

Louise E. Pilsbury | Rachel L. Allen | Martin Vordermeier
  • Special Issue
  • - Volume 2010
  • - Article ID 519589
  • - Clinical Study

Upregulation of TLR2/4 Expression in Mononuclear Cells in Postoperative Systemic Inflammatory Response Syndrome after Liver Transplantation

Ziqing Hei | Xinjin Chi | ... | Shangrong Li
  • Special Issue
  • - Volume 2010
  • - Article ID 184328
  • - Review Article

The Battle between Virus and Host: Modulation of Toll-Like Receptor Signaling Pathways by Virus Infection

Shin-ichi Yokota | Tamaki Okabayashi | Nobuhiro Fujii
  • Special Issue
  • - Volume 2010
  • - Article ID 201929
  • - Review Article

Eicosanoids in the Innate Immune Response: TLR and Non-TLR Routes

Yolanda Alvarez | Isela Valera | ... | Mariano Sánchez Crespo
  • Special Issue
  • - Volume 2010
  • - Article ID 865601
  • - Review Article

Modulation of Adult Mesenchymal Stem Cells Activity by Toll-Like Receptors: Implications on Therapeutic Potential

Olga DelaRosa | Eleuterio Lombardo
  • Special Issue
  • - Volume 2010
  • - Article ID 704202
  • - Review Article

TLR2 and TLR4 in Ischemia Reperfusion Injury

F. Arslan | B. Keogh | ... | A. E. Parker
Mediators of Inflammation
 Journal metrics
Acceptance rate35%
Submission to final decision81 days
Acceptance to publication31 days
CiteScore3.570
Impact Factor3.545
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