Mediators of Inflammation

Purinergic Signalling in Immune System Regulation in Health and Disease


Publishing date
17 Oct 2014
Status
Published
Submission deadline
30 May 2014

1Unitat d’Histologia, Departament Patologia i Terapèutica Experimental, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain

2Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Université Laval and Centre de recherche du CHU de Québec, QC, Canada

3Department of Biochemistry and Molecular Biology, Faculty of Optics, Universidad Complutense de Madrid, Madrid, Spain


Purinergic Signalling in Immune System Regulation in Health and Disease

Description

The concept of a purinergic signalling system was first proposed by Professor Geoffrey Burnstock over 30 years ago. This includes the cellular responses to purine nucleotides, such as ATP, and nucleosides, such as adenosine, that act as extracellular messengers playing a role through specific purinergic receptors. Levels of extracellular ATP and adenosine depend on cell surface enzymes generically called ectonucleotidases. Since its discovery, purinergic signalling has been shown to mediate a wide range of functions in health and disease, important among them being immunomodulation and inflammation. Recent advances have been made in therapies using purinergic-related drugs in a broad range of pathological conditions such as acute and chronic inflammatory diseases.

We invite researchers to contribute original research articles as well as review articles on the molecular and cellular aspects of purinergic signalling in relation with immune system regulation and inflammation. This includes the study of ligands, receptors, transporters, ectoenzymes, etc. Potential topics include, but are not limited to:

  • Mechanisms of nucleotides and nucleosides release (transporters, connexins, etc.)
  • Ectonucleotidases in inflammatory diseases and cancer
  • Purinergic receptors in inflammatory diseases and cancer
  • New technologies for the study of purinergic signalling
  • Advances in therapies using purinergic-related drugs in autoimmune diseases
  • Purinergic signalling in inflammatory diseases in all systems
  • Role of ATP in immunogenic cell death

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/mi/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/mi/psi/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 106863
  • - Editorial

Purinergic Signalling in Immune System Regulation in Health and Disease

Jean Sévigny | Mireia Martín-Satué | Jesús Pintor
  • Special Issue
  • - Volume 2015
  • - Article ID 630361
  • - Research Article

Modulation of Extracellular ATP Content of Mast Cells and DRG Neurons by Irradiation: Studies on Underlying Mechanism of Low-Level-Laser Therapy

Lina Wang | Lei Hu | ... | Wolfgang Schwarz
  • Special Issue
  • - Volume 2015
  • - Article ID 460610
  • - Research Article

Deficits in Endogenous Adenosine Formation by Ecto-5′-Nucleotidase/CD73 Impair Neuromuscular Transmission and Immune Competence in Experimental Autoimmune Myasthenia Gravis

Laura Oliveira | Alexandra Correia | ... | Paulo Correia-de-Sá
  • Special Issue
  • - Volume 2014
  • - Article ID 742734
  • - Review Article

Regulation of Hemichannels and Gap Junction Channels by Cytokines in Antigen-Presenting Cells

Pablo J. Sáez | Kenji F. Shoji | ... | Juan C. Sáez
  • Special Issue
  • - Volume 2014
  • - Article ID 293925
  • - Research Article

Nucleotides Regulate Secretion of the Inflammatory Chemokine CCL2 from Human Macrophages and Monocytes

K. R. Higgins | W. Kovacevic | L. Stokes
  • Special Issue
  • - Volume 2014
  • - Article ID 120673
  • - Research Article

Ecto-nucleotidases Activities in the Contents of Ovarian Endometriomas: Potential Biomarkers of Endometriosis

Laura Texidó | Claudia Romero | ... | Mireia Martín-Satué
  • Special Issue
  • - Volume 2014
  • - Article ID 134974
  • - Research Article

Macrophage P2X7 Receptor Function Is Reduced during Schistosomiasis: Putative Role of TGF-β1

Suellen D’arc Santos Oliveira | Hayandra Ferreira Nanini | ... | Robson Coutinho-Silva
  • Special Issue
  • - Volume 2014
  • - Article ID 485743
  • - Research Article

Consequences of the Lack of CD73 and Prostatic Acid Phosphatase in the Lymphoid Organs

Gennady G. Yegutkin | Kaisa Auvinen | ... | Sirpa Jalkanen
  • Special Issue
  • - Volume 2014
  • - Article ID 254640
  • - Research Article

Feed-Forward Inhibition of CD73 and Upregulation of Adenosine Deaminase Contribute to the Loss of Adenosine Neuromodulation in Postinflammatory Ileitis

Cátia Vieira | Maria Teresa Magalhães-Cardoso | ... | Paulo Correia-de-Sá
  • Special Issue
  • - Volume 2014
  • - Article ID 832103
  • - Research Article

Sustained Release of Prostaglandin E2 in Fibroblasts Expressing Ectopically Cyclooxygenase 2 Impairs P2Y-Dependent Ca2+-Mobilization

María Pimentel-Santillana | Paqui G. Través | ... | Lisardo Boscá
Mediators of Inflammation
 Journal metrics
Acceptance rate35%
Submission to final decision59 days
Acceptance to publication27 days
CiteScore3.570
Impact Factor3.545
 Submit

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.