Mediators of Inflammation

Metabolic Syndrome, Inflammation, and Cancer


Status
Published

Lead Editor

1Charles R. Drew University of Medicine and Science, Los Angeles, USA

2Harvard University, Harvard, USA

3Shanghai Jiao Tong University School of Medicine, Shanghai, China

4Nazarbayev University, Astana, Kazakhstan

5North Carolina Agricultural and Technical State University, Greensboro, USA

6Dana-Farber Cancer Institute, Boston, USA


Metabolic Syndrome, Inflammation, and Cancer

Description

The metabolic syndrome is a complex cluster of risk factors for cardiovascular disease. The inflammatory condition associated with overweight/obesity represents a triggering factor in the aetiology of the metabolic syndrome and mainly contributes to the related pathological outcomes. Stimuli including overnutrition, physical inactivity, and ageing might cause proinflammatory cytokine oversecretion and ultimately result in insulin resistance, diabetes, and its cardiovascular complications in genetically or metabolically susceptible individuals. In addition, influencing growth, apoptosis, and proliferation of cancer and stromal cells, inflammation has also been associated with various types of cancer, for example, gastric, pancreatic, esophageal, liver, bladder, and colorectal cancers.

Previous studies suggest that the metabolic syndrome may play an imperative role in the initiation, progression, and poor prognosis of some tumors. Nowadays, the causal association between metabolic syndrome and cancer is more commonly recognized; nevertheless, the precise mechanisms mediating this relationship remain poorly understood. It has become evident that the inflammatory condition associated with metabolic syndrome contributes to the development and progression of cancer. Finding novel mechanisms underlying the link between metabolic syndrome and cancer, the role of inflammation in these diseases and identification of new therapeutic targets are of significance.

In this special issue, investigators are invited to contribute original research papers and review articles that will motivate the continuous efforts to comprehend the mechanisms, production, and management related to metabolic syndrome associated cancer.

Potential topics include but are not limited to the following:

  • The link between the metabolic syndrome and cancer
  • Obesity and cancer
  • Diabetes and cancer
  • The cause for activation of inflammation in obesity/diabetes
  • Chronic inflammation in metabolic syndrome
  • Inflammation and diabetes-related cardiovascular diseases

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 8259356
  • - Editorial

Metabolic Syndrome, Inflammation, and Cancer

Yong Wu | Yunzhou Dong | ... | Lin Deng
  • Special Issue
  • - Volume 2017
  • - Article ID 5432818
  • - Research Article

Role of ARPC2 in Human Gastric Cancer

Jun Zhang | Yi Liu | ... | Hong Wang
  • Special Issue
  • - Volume 2017
  • - Article ID 5958429
  • - Research Article

Proinflammatory Cytokines IL-6 and TNF-α Increased Telomerase Activity through NF-κB/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells

Seyung S. Chung | Yong Wu | ... | Jaydutt V. Vadgama
  • Special Issue
  • - Volume 2017
  • - Article ID 8481049
  • - Research Article

Gender Disparity in the Relationship between Prevalence of Thyroid Nodules and Metabolic Syndrome Components: The SHDC-CDPC Community-Based Study

Xiaoying Ding | Ying Xu | ... | Yongde Peng
  • Special Issue
  • - Volume 2017
  • - Article ID 5032708
  • - Clinical Study

Comparison of Antidiabetic Medications during the Treatment of Atherosclerosis in T2DM Patients

Xiaojie Liu | Tao Mei | ... | Shandong Ye
  • Special Issue
  • - Volume 2017
  • - Article ID 4803156
  • - Research Article

The Metabolic Syndrome, Inflammation, and Colorectal Cancer Risk: An Evaluation of Large Panels of Plasma Protein Markers Using Repeated, Prediagnostic Samples

Sophia Harlid | Robin Myte | Bethany Van Guelpen
  • Special Issue
  • - Volume 2017
  • - Article ID 2754756
  • - Research Article

Lysophosphatidic Acid Triggers Apoptosis in HeLa Cells through the Upregulation of Tumor Necrosis Factor Receptor Superfamily Member 21

Yunzhou Dong | Yong Wu | ... | Xuemin Xu
  • Special Issue
  • - Volume 2017
  • - Article ID 3701385
  • - Research Article

FTY720 Attenuates Angiotensin II-Induced Podocyte Damage via Inhibiting Inflammatory Cytokines

Ke Su | Ping Zeng | ... | Cheng Chen
  • Special Issue
  • - Volume 2017
  • - Article ID 3709874
  • - Research Article

Elucidation of the Anti-Inflammatory Mechanisms of Bupleuri and Scutellariae Radix Using System Pharmacological Analyses

Xia Shen | Zhenyu Zhao | ... | Gang Zhang
  • Special Issue
  • - Volume 2016
  • - Article ID 1320365
  • - Research Article

Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis

Yunan Gao | Hongxiao Yang | ... | Wei Yang
Mediators of Inflammation
 Journal metrics
Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.000
Impact Factor3.758
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