Mediators of Inflammation

Antioxidative Strategy for Inflammatory Diseases

Publishing date
07 Nov 2014
Submission deadline
20 Jun 2014

1China Medical University, No. 91, Hsueh-Shih Road, Taichung 404, Taiwan

2University of California, Irvine, Department of Medicine, Med Sci 1, C240, Irvine, CA 92697, USA

3Khon Kaen University, 123 Muang District, Khon Kaen 40002, Thailand

4National Taiwan University, No.1, Section 1, Jen-Ai Road, Taipei 100, Taiwan

Antioxidative Strategy for Inflammatory Diseases


Cellular oxidants are unique classes of signaling messengers control signal transduction events to drive desirable cellular and biological responses, such as inflammatory cytokine production. However, imbalance oxidative stress causes both cellular and biological damages. Thus, it is reasonable to counterbalance oxidative stress to treat inflammation-related diseases by modulating reactive oxygen species production. Such antioxidative therapeutic strategies include various endogenous and exogenous antioxidative enzymes, antioxidants, and radical scavengers.

This special issue will allow clinicians and researchers to summarize the recent ideas with respect to the regulation of oxidative stress and provide the antioxidative therapeutic and delivery strategy for inflammatory diseases. In addition, this special issue aims to inspire novel antioxidant/drug development targeting the cellular reduction-oxidation (redox) networks to treat inflammatory diseases. Potential topics include, but are not limited to:

  • Therapeutic strategies by modulating oxidative stress in inflammatory diseases
  • Development of antioxidants (enzymes, phytomedicines, nutrients, or radical scavengers) for inflammatory diseases
  • Cellular redox networks and free radical biology in inflammation
  • Oxidative biomarkers for inflammatory diseases
  • Oxidative stress in immune cell proliferation and death
  • Redox-sensitive signal transduction pathways receptor, kinase, and transcription factor (such as Nrf2, NF-κB, or AP-1) cascades) in inflammation

Before submission authors should carefully read the journal’s Author Guidelines, which are located at Authors should submit an electronic copy of their complete manuscript through the Journal Manuscript Tracking System according to the following timetable:

Mediators of Inflammation
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