Mediators of Inflammation

Immunometabolism: Molecular Mechanisms, Diseases, and Therapies


Status
Published

Lead Editor

1Department of Physical Education, São Paulo State University, UNESP, Presidente Prudente, SP, Brazil

2University of São Paulo, São Paulo, SP, Brazil


Immunometabolism: Molecular Mechanisms, Diseases, and Therapies

Description

Chronic nonresolving inflammation is a critical condition found in several highly incident diseases such as obesity, cancer, type 2 diabetes, and atherosclerosis. Despite major implication in disease, the mechanisms underlying the development and failure to resolve such chronic inflammation are still not completely elucidated. Several lines of evidence indicate the existence of a complex interrelationship between inflammatory processes and metabolism. In this sense, changes in metabolism as those found upon overnutrition among other situations were demonstrated to modulate leukocyte function and induce inflammatory processes. Indeed, changes in the activity of the nutrient sensors mTOR and PPARs, for example, are associated with important alterations in inflammatory processes. Vice versa, inflammation and inflammatory mediators are associated with major changes in cell and tissue metabolism. For instance, chronic inflammation is associated with an impairment of insulin stimulate glucose uptake and inhibition of lipolysis.

In this special issue, we invite investigators to contribute with original research and review articles that address the complex interrelationships between immune system and metabolism. We are particularly interested in articles describing novel mechanisms of interaction between nutrients and metabolites, immune function, and inflammation and possible strategies to prevent or treat metabolic diseases. Potential topics include, but are not limited to:

  • Cell nutrient and energy sensors (G protein-coupled receptors, mTOR, PPARs, AMPK, etc.) as regulators of leukocyte function, immune responses, and inflammation
  • Modulation of lipid, protein, and carbohydrate metabolism by inflammatory mediators
  • Metabolomics and lipidomics of cells and tissue upon inflammatory conditions

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/mi/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/mi/immd/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2014
  • - Article ID 585708
  • - Editorial

Immunometabolism: Molecular Mechanisms, Diseases, and Therapies

José Cesar Rosa Neto | Fábio Santos Lira | William Tadeu Festuccia
  • Special Issue
  • - Volume 2014
  • - Article ID 426740
  • - Research Article

Vitamin C Mitigates Oxidative Stress and Tumor Necrosis Factor-Alpha in Severe Community-Acquired Pneumonia and LPS-Induced Macrophages

Yuanyuan Chen | Guangyan Luo | ... | Nanshan Zhong
  • Special Issue
  • - Volume 2014
  • - Article ID 582197
  • - Research Article

Palmitoleic Acid (N-7) Attenuates the Immunometabolic Disturbances Caused by a High-Fat Diet Independently of PPARα

Camila O. Souza | Alexandre A. S. Teixeira | ... | José C. Rosa Neto
  • Special Issue
  • - Volume 2014
  • - Article ID 243713
  • - Review Article

Interferons and Interferon Regulatory Factors in Malaria

Sin Yee Gun | Carla Claser | ... | Laurent Rénia
  • Special Issue
  • - Volume 2014
  • - Article ID 959471
  • - Research Article

A Novel Chemically Modified Curcumin Reduces Severity of Experimental Periodontal Disease in Rats: Initial Observations

Muna S. Elburki | Carlos Rossa | ... | Lorne M. Golub
  • Special Issue
  • - Volume 2014
  • - Article ID 724838
  • - Research Article

Anti-Inflammatory Effects of IKK Inhibitor XII, Thymulin, and Fat-Soluble Antioxidants in LPS-Treated Mice

E. G. Novoselova | M. O. Khrenov | ... | E. E. Fesenko
  • Special Issue
  • - Volume 2014
  • - Article ID 702473
  • - Review Article

Role of Exercise Training on Autonomic Changes and Inflammatory Profile Induced by Myocardial Infarction

Bruno Rodrigues | Fabio S. Lira | ... | Maria-Cláudia Irigoyen
  • Special Issue
  • - Volume 2014
  • - Article ID 987017
  • - Research Article

Treadmill Training Increases SIRT-1 and PGC-1α Protein Levels and AMPK Phosphorylation in Quadriceps of Middle-Aged Rats in an Intensity-Dependent Manner

Nara R. C. Oliveira | Scherolin O. Marques | ... | Cláudio T. De Souza
  • Special Issue
  • - Volume 2014
  • - Article ID 326803
  • - Review Article

Lymphocyte Glucose and Glutamine Metabolism as Targets of the Anti-Inflammatory and Immunomodulatory Effects of Exercise

Frederick Wasinski | Marcos F. Gregnani | ... | Reury F. Bacurau
  • Special Issue
  • - Volume 2014
  • - Article ID 973139
  • - Research Article

Evidences of +896 A/G TLR4 Polymorphism as an Indicative of Prevalence of Complications in T2DM Patients

Carmela Rita Balistreri | Anna Rita Bonfigli | ... | Roberto Testa
Mediators of Inflammation
 Journal metrics
Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.000
Impact Factor3.758
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