Saliva is an easy-to-handle body fluid that can be collected non-invasively and can be used for the diagnosis of several diseases, including hereditary diseases, autoimmune diseases, malignancies, infections, dental caries, and periodontal disease, by analysing several biomarkers, including inflammatory markers.

The diagnostic topic of saliva, called “Salivaomics”, includes the study of proteins (proteomics), RNAs (transcriptomics), metabolites (metabolomics), microRNAs, microbiota (microbiome), and inflammatory markers (inflammasome). The diagnostic potential of saliva is well established by studies that revealed that, like serum or plasma, saliva contains hormones, antibodies, growth factors, enzymes, and microbes and their products. Though the low concentration of some analytes in saliva compared to the blood previously proved challenging, the advent of highly sensitive molecular methods and nanotechnology have, to a large extent, circumvented this limitation.

The aim of this Special Issue is to highlight studies concerning inflammatory markers in saliva, as a diagnostic tool or a pathway to understand the pathogenesis of oral and/or systemic diseases. Original research and review articles are welcome.

Potential topics include but are not limited to the following:

• Influence of inflammatory markers in oral dysbiosis
• Salivary inflammatory biomarkers in periodontal disease and periimplantitis
• Infectious diseases and salivary biomarkers
• Salivary biomarkers in the diagnosis and prognosis of potentially malignant disorders and cancer
• Salivary inflammatory biomarkers in systemic health and disease
• Periodontal medicine and salivary inflammatory biomarkers
• Saliva and liquid biopsy
• Point-of-care devices development based on salivary inflammatory markers