Mediators of Inflammation

Th17 Cytokines and Barrier Functions


Publishing date
12 Feb 2016
Status
Published
Submission deadline
25 Sep 2015

Lead Editor

1Children’s Hospital of Pittsburgh, Pittsburgh, USA

2MedImmune, Gaithersburg, USA

3Slovak Academy of Sciences, Štefánikova, Slovakia

4Xinqiao Hospital of Third Military Medical University, Chongqing, China

5Baylor College of Medicine, Houston, USA


Th17 Cytokines and Barrier Functions

Description

IL-17 functions in host defense against extracellular bacterial and fungal infections and contributes to the pathogenesis of various autoimmune inflammatory diseases. CD4+ Th17 cells are a major source of IL-17 in vivo and play a central role in the pathogenesis of autoimmune diseases. Since the discovery of Th17 cells in 2005, there has been rapid progress in our understanding of the roles of IL-17-producing T cells in innate immunity to infection, the plasticity of Th17 cells, and genetic diseases associated with Th17 defects. The IL-17 pathway has been shown to be an attractive therapeutic target in many autoimmune and inflammatory disorders.

Most Th17 cells were found to reside in the barrier tissues, including respiratory and intestinal tracts as well as skin. Myelin-specific Th17 cells can also penetrate the blood-brain barrier (BBB) under inflammatory conditions and cause multiple sclerosis (MS). Cytokines produced by these Th17 and non-Th17 cells including γδ-T cells and innate lymphoid cells play critical roles in regulating tissue homeostasis and inflammation.

We invite scientists to contribute original research and review articles that will help the field to understand the role of IL-17-producing cells in diseases. We encourage submission of manuscripts on studies using animal models as well as disease progression in patients who suffer inflammatory conditions in barrier tissues including cancers.

Potential topics include, but are not limited to:

  • Identification and regulation of specific cell types of IL-17 producing cells in various types of barrier tissues as well as IL-17-producing cells penetrate barriers
  • Antigen specificity of Th17 cells in barrier tissues
  • Mechanisms by which IL-17-producing cells penetrate barriers
  • Aberrant expression of IL-17 and IL-17 signatures in animal models and clinical specimens
  • Cross talk between IL-17 signaling and known pathways in disease pathogenesis and progression
  • Genetic variations in the IL-17 pathway and susceptibility to diseases
  • T-cell plasticity, preferentially Th17 cell, in autoimmune disease including MS and in tumor development and cancer immunotherapy

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 7179214
  • - Editorial

Th17 Cytokines and Barrier Functions

Guansong Wang | Musheng Bao | ... | Kong Chen
  • Special Issue
  • - Volume 2016
  • - Article ID 1732352
  • - Research Article

Association between Serum Interleukin-17A Level and High-Altitude Deacclimatization Syndrome

Binfeng He | Hongli Li | ... | Xiaolan Guo
  • Special Issue
  • - Volume 2016
  • - Article ID 3296307
  • - Research Article

Correlation of Surface Toll-Like Receptor 9 Expression with IL-17 Production in Neutrophils during Septic Peritonitis in Mice Induced by E. coli

Yunjia Ren | Li Hua | ... | Liying Wang
  • Special Issue
  • - Volume 2016
  • - Article ID 7089137
  • - Research Article

The Th17/Treg Immune Imbalance in Ulcerative Colitis Disease in a Chinese Han Population

Yang Gong | Yifan Lin | ... | Miao Jiang
  • Special Issue
  • - Volume 2016
  • - Article ID 9834020
  • - Review Article

Acinetobacter baumannii Infection and IL-17 Mediated Immunity

Zihe Yan | Junjun Yang | ... | Kong Chen
  • Special Issue
  • - Volume 2016
  • - Article ID 5314541
  • - Review Article

Th17 Cells Pathways in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders: Pathophysiological and Therapeutic Implications

Giordani Rodrigues Dos Passos | Douglas Kazutoshi Sato | ... | Kazuo Fujihara
  • Special Issue
  • - Volume 2016
  • - Article ID 6470364
  • - Review Article

Does IL-17 Respond to the Disordered Lung Microbiome and Contribute to the Neutrophilic Phenotype in Asthma?

Xu Yang | Yunqiu Jiang | Changzheng Wang
  • Special Issue
  • - Volume 2016
  • - Article ID 2979846
  • - Research Article

Interleukin-17A Gene Variability in Patients with Type 1 Diabetes Mellitus and Chronic Periodontitis: Its Correlation with IL-17 Levels and the Occurrence of Periodontopathic Bacteria

Petra Borilova Linhartova | Jakub Kastovsky | ... | Lydie Izakovicova Holla
  • Special Issue
  • - Volume 2016
  • - Article ID 6145810
  • - Review Article

Enigma of IL-17 and Th17 Cells in Rheumatoid Arthritis and in Autoimmune Animal Models of Arthritis

Reka Kugyelka | Zoltan Kohl | ... | Ferenc Boldizsar
  • Special Issue
  • - Volume 2016
  • - Article ID 9798206
  • - Research Article

Th17 Cytokines Disrupt the Airway Mucosal Barrier in Chronic Rhinosinusitis

Mahnaz Ramezanpour | Sophia Moraitis | ... | Sarah Vreugde
Mediators of Inflammation
 Journal metrics
Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.000
Impact Factor3.758
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