Mediators of Inflammation

Natural Anti-Inflammatory Products/Compounds: Hopes and Reality


Publishing date
23 Oct 2015
Status
Published
Submission deadline
05 Jun 2015

1University of Naples Federico II, Naples, Italy

2University of Oxford, Oxford, UK

2University of Naples Federico II, Naples, Italy


Natural Anti-Inflammatory Products/Compounds: Hopes and Reality

Description

Inflammation is a complex biological response to injury as a result of different stimuli such as pathogens, damaged cells, or irritants. It is considered a protective measure taken by the organism to remove harmful stimuli and to begin the healing process. In this scenario, local signals at the sites of inflammation mediate rapid cell recruitment and dictate differentiation programs whereby these cells drive clearance of inflammatory inducers and promote tissue homeostasis restoration. However, persistent inflammatory stimuli or disregulation of mechanisms of the restoration phase can lead to chronic inflammation.

Nowadays, the commercially approved anti-inflammatory drugs mainly used for such condition are represented by nonsteroidal anti-inflammatory drugs (NSAID), glucocorticoids (SAID), and in some cases immunosuppressant and/or biological drugs. These agents are effective for the relief of the main inflammatory symptoms. However, they induce severe side effects, whereas, most of them, are inadequate for chronic use.

In this context, the demand of new effective and safely anti-inflammatory drugs has furthered research into new therapeutic approaches. The recent and emerging scientific community slant is oriented to the herbal medicines, since, from the Ancient time, they represent a treasure for the discovery of new active compounds and for the development of new drugs and potentially useful therapeutic agents. This research direction is greatly supported by a remarkable amount of preclinical and clinical investigations that highlight the effectiveness of different plant extract and/or plant secondary metabolites in reducing tissue inflammation in vivo and in modulating molecular pathways involved in inflammatory responses in vitro.

Starting from these premises we would be pleased to invite investigators to submit original research papers and/or review articles that will stimulate the continuing efforts to (i) study the anti-inflammatory properties of active natural-derived compounds and/or botanical extracts using several experimental models of inflammation, both in vivo and in vitro; (ii) deepen the pathways involved in their displayed effects; and (iii) evaluate the translation feasibility of the preclinical studies into the clinical attention, considering the well-known safety profile of natural products.

Potential topics include, but are not limited to:

  • Elucidation of the role/mechanism of plant-derived metabolites or botanical extracts during acute and/or chronic inflammation
  • Identification of new natural compounds as functional regulators of inflammatory cells
  • Investigation of the inflammation preventive potential of natural products and related synthetic entities

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 374239
  • - Editorial

Natural Anti-Inflammatory Products/Compounds: Hopes and Reality

Barbara Romano | Asif Jilani Iqbal | Francesco Maione
  • Special Issue
  • - Volume 2015
  • - Article ID 720171
  • - Research Article

Moringa oleifera Flower Extract Suppresses the Activation of Inflammatory Mediators in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages via NF-κB Pathway

Woan Sean Tan | Palanisamy Arulselvan | ... | Sharida Fakurazi
  • Special Issue
  • - Volume 2015
  • - Article ID 179616
  • - Review Article

Botanical Drugs as an Emerging Strategy in Inflammatory Bowel Disease: A Review

Francesca Algieri | Alba Rodriguez-Nogales | ... | Julio Galvez
  • Special Issue
  • - Volume 2015
  • - Article ID 835910
  • - Review Article

Natural Products: Insights into Leishmaniasis Inflammatory Response

Igor A. Rodrigues | Ana Maria Mazotto | ... | Alane B. Vermelho
  • Special Issue
  • - Volume 2015
  • - Article ID 263543
  • - Review Article

Marine Diterpenoids as Potential Anti-Inflammatory Agents

Yisett González | Daniel Torres-Mendoza | ... | Patricia L. Fernandez
  • Special Issue
  • - Volume 2015
  • - Article ID 350564
  • - Research Article

Anti-Inflammatory Effect of 1,3,5,7-Tetrahydroxy-8-isoprenylxanthone Isolated from Twigs of Garcinia esculenta on Stimulated Macrophage

Dan-Dan Zhang | Hong Zhang | ... | Hong-Xi Xu
  • Special Issue
  • - Volume 2015
  • - Article ID 372750
  • - Research Article

Downregulation of mPGES-1 Expression via EGR1 Plays an Important Role in Inhibition of Caffeine on PGE2 Synthesis of HBx(+) Hepatocytes

Yan Ma | Xiaoqian Wang | Nanhong Tang
  • Special Issue
  • - Volume 2015
  • - Article ID 780149
  • - Research Article

Therapeutic Effect of Chenodeoxycholic Acid in an Experimental Rabbit Model of Osteoarthritis

Zhao-wei Yan | Ji Dong | ... | Chun-yan He
Mediators of Inflammation
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Acceptance rate35%
Submission to final decision77 days
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