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Minimally Invasive Surgery
Volume 2018, Article ID 5230350, 15 pages
Review Article

Spinal Biologics in Minimally Invasive Lumbar Surgery

Department of Orthopedic Surgery, Northwestern University Feinberg School of Medicine, 676 N. Saint Clair St., Suite #1350, Chicago, IL 60611, USA

Correspondence should be addressed to Wellington K. Hsu; moc.oohay@ushkw

Received 22 December 2017; Accepted 25 February 2018; Published 5 April 2018

Academic Editor: Brian J. Dlouhy

Copyright © 2018 Kevin Y. Chang and Wellington K. Hsu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


As the use of minimally invasive spine (MIS) fusion approaches continues to grow, increased scrutiny is being placed on its outcomes and efficacies against traditional open fusion surgeries. While there are many factors that contribute to the success of achieving spinal arthrodesis, selecting the optimal fusion biologic remains a top priority. With an ever-expanding market of bone graft substitutes, it is important to evaluate each of their use as it pertains to MIS techniques. This review will summarize the important characteristics and properties of various spinal biologics used in minimally invasive lumbar surgeries and compare their fusion rates via a systematic review of published literature.