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Minimally Invasive Surgery
Volume 2018, Article ID 5230350, 15 pages
https://doi.org/10.1155/2018/5230350
Review Article

Spinal Biologics in Minimally Invasive Lumbar Surgery

Department of Orthopedic Surgery, Northwestern University Feinberg School of Medicine, 676 N. Saint Clair St., Suite #1350, Chicago, IL 60611, USA

Correspondence should be addressed to Wellington K. Hsu; moc.oohay@ushkw

Received 22 December 2017; Accepted 25 February 2018; Published 5 April 2018

Academic Editor: Brian J. Dlouhy

Copyright © 2018 Kevin Y. Chang and Wellington K. Hsu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Jaikumar, D. H. Kim, and A. C. Kam, “History of minimally invasive spine surgery,” Neurosurgery, vol. 51, no. 5, pp. 1–14, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. T. G. Obenchain, “Laparoscopic Lumbar Discectomy: Case Report,” World Journal of Laparoscopic Surgery, vol. 1, no. 3, pp. 145–149, 1991. View at Publisher · View at Google Scholar
  3. S. S. Rajaee, H. W. Bae, L. E. A. Kanim, and R. B. Delamarter, “Spinal fusion in the United States: analysis of trends from 1998 to 2008,” The Spine Journal, vol. 37, no. 1, pp. 67–76, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. F. M. Phillips, I. Cheng, Y. R. Rampersaud et al., “Breaking through the 'glass ceiling' of minimally invasive spine surgery,” The Spine Journal, vol. 41, S8, pp. S39–S43, 2016. View at Publisher · View at Google Scholar · View at Scopus
  5. A. F. Cannestra, M. D. Peterson, S. R. Parker, T. F. Roush, J. V. Bundy, and A. W. Turner, “MIS Expandable Interbody Spacers,” The Spine Journal, p. 1, 2016. View at Publisher · View at Google Scholar
  6. R. J. Mobbs et al., “Lumbar interbody fusion: techniques, indications and comparison of interbody fusion options including PLIF, TLIF, MI-TLIF, OLIF/ATP, LLIF and ALIF,” Journal of Spine Surgery, vol. 1, no. 1, p. 18, 2015. View at Google Scholar
  7. M. Mica, L. Voronov, G. Carandang, R. Havey, B. Wojewnik, and A. Patwardhan, “Biomechanics of an Expandable Lumbar Interbody Fusion Cage Deployed Through Transforaminal Approach,” International Journal of Spine Surgery, vol. 11, no. 4, pp. 193–200, 2017. View at Publisher · View at Google Scholar
  8. R. J. Mobbs, A. Loganathan, V. Yeung, and P. J. Rao, “Indications for Anterior Lumbar Interbody Fusion,” Orthopaedic Surgery, vol. 5, no. 3, pp. 153–163, 2013. View at Publisher · View at Google Scholar
  9. L. Pimenta, A. W. L. Turner, Z. A. Dooley, R. D. Parikh, and M. D. Peterson, “Biomechanics of lateral interbody spacers: Going wider for going stiffer,” The Scientific World Journal, vol. 2012, Article ID 381814, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. P. V. Giannoudis, H. Dinopoulos, and E. Tsiridis, “Bone substitutes: an update,” Injury, vol. 36, supplement 3, pp. S20–S27, 2005. View at Google Scholar · View at Scopus
  11. T. Albrektsson and C. Johansson, “Osteoinduction, osteoconduction and osseointegration,” European Spine Journal, vol. 10, no. 2, pp. S96–S101, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. I. H. Kalfas, “Principles of bone healing,” Neurosurgical Focus, vol. 10, no. 4, p. E1, 2001. View at Google Scholar · View at Scopus
  13. J.-S. Yoo, S.-H. Min, and S.-H. Yoon, “Fusion rate according to mixture ratio and volumes of bone graft in minimally invasive transforaminal lumbar interbody fusion: minimum 2-year follow-up,” European Journal of Orthopaedic Surgery and Traumatology, vol. 25, pp. 183–189, 2015. View at Publisher · View at Google Scholar · View at Scopus
  14. C. Schizas, N. Tzinieris, E. Tsiridis, and V. Kosmopoulos, “Minimally invasive versus open transforaminal lumbar interbody fusion: Evaluating initial experience,” International Orthopaedics, vol. 33, no. 6, pp. 1683–1688, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. D. Zhang, K. Mao, and X. Qiang, “Comparing minimally invasive transforaminal lumbar interbody fusion and posterior lumbar interbody fusion for spondylolisthesis,” Medicine (United States), vol. 96, no. 37, Article ID e8011, 2017. View at Publisher · View at Google Scholar · View at Scopus
  16. D. V. Rajakumar, A. Hari, M. Krishna, A. Sharma, and M. Reddy, “Complete anatomic reduction and monosegmental fusion for lumbar spondylolisthesis of Grade II and higher: Use of the minimally invasive “rocking” technique,” Neurosurgical Focus, vol. 43, no. 2, article no. E12, 2017. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Yang, L. Zhang, B. Liu et al., “Hidden and overall haemorrhage following minimally invasive and open transforaminal lumbar interbody fusion,” Journal of Orthopaedics and Traumatology, pp. 1–6, 2017. View at Publisher · View at Google Scholar · View at Scopus
  18. P. Huang, Y. Wang, J. Xu et al., “Minimally invasive unilateral pedicle screws and a translaminar facet screw fixation and interbody fusion for treatment of single-segment lower lumbar vertebral disease: Surgical technique and preliminary clinical results,” Journal of Orthopaedic Surgery and Research, vol. 12, no. 1, article no. 117, 2017. View at Publisher · View at Google Scholar · View at Scopus
  19. W. Choi, J. Kim, J. Hur, and J. Seong, “Minimally invasive transforaminal lumbar interbody fusion using banana-shaped and straight cages: radiological and clinical results from a prospective randomized clinical trial,” Neurosurgery, vol. 82, no. 3, pp. 289–298, 2018. View at Publisher · View at Google Scholar
  20. Y. Lv, J. Chen, J. Chen et al., “Three-year postoperative outcomes between MIS and conventional TLIF in1-segment lumbar disc herniation,” Minimally Invasive Therapy & Allied Technologies, vol. 26, no. 3, pp. 168–176, 2017. View at Publisher · View at Google Scholar · View at Scopus
  21. G. Fan, H. Zhang, X. Guan et al., “Patient-reported and radiographic outcomes of minimally invasive transforaminal lumbar interbody fusion for degenerative spondylolisthesis with or without reduction: A comparative study,” Journal of Clinical Neuroscience, vol. 33, pp. 111–118, 2016. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Tian and X. Liu, “Clinical outcomes of two minimally invasive transforaminal lumbar interbody fusion (TLIF) for lumbar degenerative diseases,” European Journal of Orthopaedic Surgery and Traumatology, vol. 26, no. 7, pp. 745–751, 2016. View at Publisher · View at Google Scholar · View at Scopus
  23. G. Fan, G. Gu, Y. Zhu et al., “Minimally invasive transforaminal lumbar interbody fusion for isthmic spondylolisthesis: in situ versus reduction,” World Neurosurgery, vol. 90, pp. 580–587.E1, 2016. View at Publisher · View at Google Scholar · View at Scopus
  24. Y. Yang et al., “Microendoscopy-assisted minimally invasive transforaminal lumbar interbody fusion for lumbar degenerative disease: short-term and medium-term outcomes,” International Journal of Clinical and Experimental Medicine, vol. 8, no. 11, pp. 21319–26, 2015. View at Google Scholar
  25. X. Liu, G. Li, J. Wang, and H. Zhang, “Minimally invasive unilateral vs. bilateral pedicle screw fixation and lumbar interbody fusion in treatment of multi-segment lumbar degenerative disorders,” Medical Science Monitor, vol. 21, article no. A494, pp. 3652–3657, 2015. View at Publisher · View at Google Scholar · View at Scopus
  26. W.-C. Lee, J.-Y. Park, K. H. Kim et al., “Minimally Invasive Transforaminal Lumbar Interbody Fusion in Multilevel: Comparison with Conventional Transforaminal Interbody Fusion,” World Neurosurgery, vol. 85, pp. 236–243, 2016. View at Publisher · View at Google Scholar · View at Scopus
  27. C. Chen, X. Cao, L. Zou, G. Hao, Z. Zhou, and G. Zhang, “Minimally invasive unilateral versus bilateral technique in performing single-segment pedicle screw fixation and lumbar interbody fusion,” Journal of Orthopaedic Surgery and Research, vol. 10, no. 1, article no. 112, 2015. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Y. Kim, J. Y. Park, K. H. Kim et al., “Minimally invasive transforaminal lumbar interbody fusion for spondylolisthesis: comparison between isthmic and degenerative spondylolisthesis,” World Neurosurgery, vol. 84, no. 5, pp. 1284–1293, 2015. View at Publisher · View at Google Scholar · View at Scopus
  29. W. Zhang, X. Li, X. Shang et al., “Modified minimally invasive transforaminal lumbar interbody fusion using a trans-multifidus approach: A safe and effective alternative to open-TLIF,” Journal of Orthopaedic Surgery and Research, vol. 10, no. 1, article no. 93, 2015. View at Publisher · View at Google Scholar · View at Scopus
  30. G. Gu, H. Zhang, G. Fan et al., “Clinical and radiological outcomes of unilateral versus bilateral instrumentation in two-level degenerative lumbar diseases,” European Spine Journal, vol. 24, no. 8, pp. 1640–1648, 2015. View at Publisher · View at Google Scholar · View at Scopus
  31. X. Shen, H. Zhang, X. Gu, G. Gu, X. Zhou, and S. He, “Unilateral versus bilateral pedicle screw instrumentation for single-level minimally invasive transforaminal lumbar interbody fusion,” Journal of Clinical Neuroscience, vol. 21, no. 9, pp. 1612–1616, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. G. Gu, H. Zhang, G. Fan et al., “Comparison of minimally invasive versus open transforaminal lumbar interbody fusion in two-level degenerative lumbar disease,” International Orthopaedics, vol. 38, no. 4, pp. 817–824, 2014. View at Publisher · View at Google Scholar · View at Scopus
  33. U. Y. Choi, J. Y. Park, K. H. Kim et al., “Unilateral versus bilateral percutaneous pedicle screw fixation in minimally invasive transforaminal lumbar interbody fusion,” Neurosurgical Focus, vol. 35, no. 2, article no. E11, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. E. Sonmez, I. Coven, F. Sahinturk, C. Yilmaz, and H. Caner, “Unilateral percutaneous pedicle screw instrumentation with minimally invasive tlif for the treatment of recurrent lumbar disk disease: 2 years follow-up,” Turkish Neurosurgery, vol. 23, no. 3, pp. 372–378, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. J. Wang, Y. Zhou, Z. Feng Zhang, C. Qing Li, W. Jie Zheng, and J. Liu, “Comparison of the clinical outcome in overweight or obese patients after minimally invasive versus open transforaminal lumbar interbody fusion,” Journal of Spinal Disorders & Techniques, vol. 27, no. 4, pp. 202–206, 2014. View at Publisher · View at Google Scholar · View at Scopus
  36. M. K. Kasliwal and H. Deutsch, “Clinical and radiographic outcomes using local bone shavings as autograft in minimally invasive transforaminal lumbar interbody fusion,” World Neurosurgery, vol. 78, no. 1-2, pp. 185–190, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. K.-M. Scheufler, H. Dohmen, and V. I. Vougioukas, “Percutaneous transforaminal lumbar interbody fusion for the treatment of degenerative lumbar instability,” Neurosurgery, vol. 60, 2, no. 4, pp. 203–212, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. D. Serban, N. Calina, and G. Tender, “Standard versus Minimally Invasive Transforaminal Lumbar Interbody Fusion: A Prospective Randomized Study,” BioMed Research International, vol. 2017, Article ID 7236970, 2017. View at Publisher · View at Google Scholar · View at Scopus
  39. S. Fan, X. Zhao, F. Zhao, and X. Fang, “Minimally invasive transforaminal lumbar interbody fusion for the treatment of degenerative lumbar diseases,” The Spine Journal, vol. 35, no. 17, pp. 1615–1620, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. C. W. B. Peng, W. M. Yue, S. Y. Poh, W. Yeo, and S. B. Tan, “Clinical and radiological outcomes of minimally invasive versus open transforaminal lumbar interbody fusion,” The Spine Journal, vol. 34, no. 13, pp. 1385–1389, 2009. View at Publisher · View at Google Scholar · View at Scopus
  41. S. Ohtori, C. Mannoji, S. Orita et al., “Mini-open anterior retroperitoneal lumbar interbody fusion: Oblique lateral interbody fusion for degenerated lumbar spinal kyphoscoliosis,” Asian Spine Journal, vol. 9, no. 4, pp. 565–572, 2015. View at Publisher · View at Google Scholar · View at Scopus
  42. E.-X. He, J. Guo, Q.-J. Ling, Z.-X. Yin, Y. Wang, and M. Li, “Application of a narrow-surface cage in full endoscopic minimally invasive transforaminal lumbar interbody fusion,” International Journal of Surgery, vol. 42, pp. 83–89, 2017. View at Publisher · View at Google Scholar · View at Scopus
  43. H.-J. Lee, J.-S. Kim, and K.-S. Ryu, “Minimally Invasive TLIF Using Unilateral Approach and Single Cage at Single Level in Patients over 65,” BioMed Research International, vol. 2016, Article ID 4679865, 2016. View at Publisher · View at Google Scholar · View at Scopus
  44. J. K. Lim and S. M. Kim, “Radiographic Results of Minimally Invasive (MIS) Lumbar Interbody Fusion (LIF) Compared with Conventional Lumbar Interbody Fusion,” Korean Journal of Spine, vol. 10, no. 2, p. 65, 2013. View at Publisher · View at Google Scholar
  45. M.-C. Kim, H.-T. Chung, D.-J. Kim, S.-H. Kim, and S.-H. Jeon, “The clinical and radiological outcomes of minimally invasive transforaminal lumbar interbody single level fusion,” Asian Spine Journal, vol. 5, no. 2, pp. 111–116, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. J.-S. Jang and S.-H. Lee, “Minimally invasive transforaminal lumbar interbody fusion with ipsilateral pedicle screw and contralateral facet screw fixation.,” Journal of Neurosurgery: Spine, vol. 3, no. 3, pp. 218–223, 2005. View at Publisher · View at Google Scholar · View at Scopus
  47. A. Ahmadian, K. Bach, B. Bolinger et al., “Stand-alone minimally invasive lateral lumbar interbody fusion: Multicenter clinical outcomes,” Journal of Clinical Neuroscience, vol. 22, no. 4, pp. 740–746, 2015. View at Publisher · View at Google Scholar · View at Scopus
  48. A. H. Hawasli, J. M. Khalifeh, A. Chatrath, C. K. Yarbrough, and W. Z. Ray, “Minimally invasive transforaminal lumbar interbody fusion with expandable versus static interbody devices: Radiographic assessment of sagittal segmental and pelvic parameters,” Neurosurgical Focus, vol. 43, no. 2, article no. E10, 2017. View at Publisher · View at Google Scholar · View at Scopus
  49. S. V. Nandyala, S. J. Fineberg, M. Pelton, and K. Singh, “Minimally invasive transforaminal lumbar interbody fusion: one surgeon's learning curve,” The Spine Journal, vol. 14, no. 8, pp. 1460–1465, 2014. View at Publisher · View at Google Scholar · View at Scopus
  50. K. R. M. Woods, J. B. Billys, and R. A. Hynes, “Technical description of oblique lateral interbody fusion at L1–L5 (OLIF25) and at L5–S1 (OLIF51) and evaluation of complication and fusion rates,” The Spine Journal, vol. 17, no. 4, pp. 545–553, 2017. View at Publisher · View at Google Scholar · View at Scopus
  51. H. Abbasi, L. Miller, A. Abbasi, V. Orandi, and K. Khaghany, “Minimally Invasive Scoliosis Surgery with Oblique Lateral Lumbar Interbody Fusion: Single Surgeon Feasibility Study,” Cureus, vol. 9, no. 6, article e1389, 2017. View at Publisher · View at Google Scholar
  52. W. B. Rodgers, E. J. Gerber, and J. A. Rodgers, “Clinical and radiographic outcomes of extreme lateral approach to interbody fusion with β-tricalcium phosphate and hydroxyapatite composite for lumbar degenerative conditions,” International Journal of Spine Surgery, vol. 6, no. 1, pp. 24–28, 2012. View at Publisher · View at Google Scholar · View at Scopus
  53. W. B. Rodgers, E. J. Gerber, and J. R. Patterson, “Fusion after minimally disruptive anterior lumbar interbody fusion: Analysis of extreme lateral interbody fusion by computed tomography,” SAS Journal, vol. 4, no. 2, pp. 63–66, 2010. View at Publisher · View at Google Scholar · View at Scopus
  54. W.-S. Choi, J.-S. Kim, K.-S. Ryu, J.-W. Hur, and J.-H. Seong, “Minimally invasive transforaminal lumbar interbody fusion at L5-S1 through a unilateral approach: technical feasibility and outcomes,” BioMed Research International, vol. 2016, Article ID 2518394, 8 pages, 2016. View at Publisher · View at Google Scholar
  55. C.-H. Kuo, P.-Y. Chang, J.-C. Wu et al., “Dynamic stabilization for L4-5 spondylolisthesis: Comparison with minimally invasive transforaminal lumbar interbody fusion with more than 2 years of follow-up,” Neurosurgical Focus, vol. 40, no. 1, article no. E3, 2016. View at Publisher · View at Google Scholar · View at Scopus
  56. Y. Park, J. W. Ha, Y. T. Lee, and N. Y. Sung, “Minimally invasive transforaminal lumbar interbody fusion for spondylolisthesis and degenerative spondylosis: 5-year results,” Clinical Orthopaedics and Related Research, vol. 472, no. 6, pp. 1813–1823, 2014. View at Publisher · View at Google Scholar · View at Scopus
  57. K. H. Lee, W. M. Yue, W. Yeo, H. Soeharno, and S. B. Tan, “Clinical and radiological outcomes of open versus minimally invasive transforaminal lumbar interbody fusion,” European Spine Journal, vol. 21, no. 11, pp. 2265–2270, 2012. View at Publisher · View at Google Scholar · View at Scopus
  58. Y. Park, J. W. Ha, Y. T. Lee, H. C. Oh, J. H. Yoo, and H. B. Kim, “Surgical outcomes of minimally invasive transforaminal lumbar interbody fusion for the treatment of spondylolisthesis and degenerative segmental instability,” Asian Spine Journal, vol. 5, no. 4, pp. 228–236, 2011. View at Publisher · View at Google Scholar · View at Scopus
  59. J.-S. Yoo, S.-H. Min, S.-H. Yoon, and C.-H. Hwang, “Paraspinal muscle changes of unilateral multilevel minimally invasive transforaminal interbody fusion,” Journal of Orthopaedic Surgery and Research, vol. 9, p. 130, 2014. View at Publisher · View at Google Scholar · View at Scopus
  60. J.-H. Lin and Y.-H. Chiang, “Unilateral approach for bilateral foramen decompression in minimally invasive transforaminal interbody fusion,” World Neurosurgery, vol. 82, no. 5, pp. 891–896, 2014. View at Publisher · View at Google Scholar · View at Scopus
  61. G. M. Malham, N. J. Ellis, R. M. Parker et al., “Maintenance of segmental lordosis and disk height in stand-alone and instrumented extreme lateral interbody fusion (XLIF),” Clinical Spine Surgery, vol. 30, no. 2, pp. E90–E98, 2017. View at Publisher · View at Google Scholar · View at Scopus
  62. B. Waddell, D. Briski, R. Qadir et al., “Lateral lumbar interbody fusion for the correction of spondylolisthesis and adult degenerative scoliosis in high-risk patients: early radiographic results and complications,” The Ochsner Journal, vol. 14, no. 1, pp. 23–31, 2014. View at Google Scholar · View at Scopus
  63. E. Dakwar, R. F. Cardona, D. A. Smith, and J. S. Uribe, “Early outcomes and safety of the minimally invasive, lateral retroperitoneal transpsoas approach for adult degenerative scoliosis.,” Neurosurgical Focus, vol. 28, no. 3, p. E8, 2010. View at Publisher · View at Google Scholar · View at Scopus
  64. M. Alimi et al., “Radiographic and clinical outcome of silicate-substituted calcium phosphate (si-cap) ceramic bone graft in spinal fusion procedures,” Clinical Spine Surgery, vol. 30, no. 6, pp. E845–e852, 2017. View at Google Scholar
  65. R. M. Parker and G. M. Malham, “Comparison of a calcium phosphate bone substitute with recombinant human bone morphogenetic protein-2: a prospective study of fusion rates, clinical outcomes and complications with 24-month follow-up,” European Spine Journal, vol. 26, no. 3, pp. 754–763, 2017. View at Publisher · View at Google Scholar · View at Scopus
  66. P. Berjano, F. Langella, M. Damilano et al., “Fusion rate following extreme lateral lumbar interbody fusion,” European Spine Journal, vol. 24, supplement 3, pp. 369–371, 2015. View at Publisher · View at Google Scholar
  67. L. Marchi, N. Abdala, L. Oliveira, R. Amaral, E. Coutinho, and L. Pimenta, “Radiographic and clinical evaluation of cage subsidence after stand-alone lateral interbody fusion,” Journal of Neurosurgery: Spine, vol. 19, no. 1, pp. 110–118, 2013. View at Publisher · View at Google Scholar · View at Scopus
  68. L. Pimenta, L. Marchi, L. Oliveira, E. Coutinho, and R. Amaral, “A prospective, randomized, controlled trial comparing radiographic and clinical outcomes between stand-alone lateral interbody lumbar fusion with either silicate calcium phosphate or rh-BMP2,” Journal of Neurological Surgery Part A: Central European Neurosurgery, vol. 74, no. 6, pp. 343–350, 2013. View at Publisher · View at Google Scholar · View at Scopus
  69. M. Y. Wang and J. Grossman, “Endoscopic minimally invasive transforaminal interbody fusion without general anesthesia: initial clinical experience with 1-year follow-up,” Neurosurgical Focus, vol. 40, no. 2, p. E13, 2016. View at Publisher · View at Google Scholar · View at Scopus
  70. M. M. A. Siddiqui, A. R. P. Sta Ana, W. Yeo, and W.-M. Yue, “Bone morphogenic protein is a viable adjunct for fusion in minimally invasive transforaminal lumbar interbody fusion,” Asian Spine Journal, vol. 10, no. 6, pp. 1091–1099, 2016. View at Publisher · View at Google Scholar · View at Scopus
  71. A. Tsahtsarlis and M. Wood, “Minimally invasive transforaminal lumber interbody fusion and degenerative lumbar spine disease,” European Spine Journal, vol. 21, no. 11, pp. 2300–2305, 2012. View at Publisher · View at Google Scholar · View at Scopus
  72. D. Rouben, M. Casnellie, and M. Ferguson, “Long-term durability of minimal invasive posterior transforaminal lumbar interbody fusion: A clinical and radiographic follow-up,” Journal of Spinal Disorders & Techniques, vol. 24, no. 5, pp. 288–296, 2011. View at Publisher · View at Google Scholar · View at Scopus
  73. P. Park and K. T. Foley, “Minimally invasive transforaminal lumbar interbody fusion with reduction of spondylolisthesis: technique and outcomes after a minimum of 2 years' follow-up,” Neurosurgical Focus, vol. 25, no. 2, article no. E16, 2008. View at Publisher · View at Google Scholar · View at Scopus
  74. H. Deutsch and M. J. Musacchio Jr., “Minimally invasive transforaminal lumbar interbody fusion with unilateral pedicle screw fixation.,” Neurosurgical Focus, vol. 20, no. 3, p. E10, 2006. View at Google Scholar · View at Scopus
  75. A. E. Castellvi, T. W. Nienke, G. A. Marulanda, R. D. Murtagh, and B. G. Santoni, “Indirect decompression of lumbar stenosis with transpsoas interbody cages and percutaneous posterior instrumentation,” Clinical Orthopaedics and Related Research, vol. 472, no. 6, pp. 1784–1791, 2014. View at Publisher · View at Google Scholar · View at Scopus
  76. H. E. Aryan, C. B. Newman, J. J. Gold, F. L. Acosta Jr., C. Coover, and C. P. Ames, “Percutaneous axial lumbar interbody fusion (AxiaLIF) of the L5-S1 segment: Initial clinical and radiographic experience,” Minimally Invasive Neurosurgery, vol. 51, no. 4, pp. 225–230, 2008. View at Publisher · View at Google Scholar · View at Scopus
  77. N. S. Dahdaleh, A. T. Nixon, C. D. Lawton, A. P. Wong, Z. A. Smith, and R. G. Fessler, “Outcome following unilateral versus bilateral instrumentation in patients undergoing minimally invasive transforaminal lumbar interbody fusion: A single-center randomized prospective study,” Neurosurgical Focus, vol. 35, no. 2, article no. E13, 2013. View at Publisher · View at Google Scholar · View at Scopus
  78. V. M. Goldberg and S. Akhavan, “Biology of Bone Grafts,” in in Bone Regeneration and Repair: Biology and Clinical Applications, J. R. Lieberman and and G. E. Friedlaender, Eds., pp. 57–65, Humana Press, 2005. View at Google Scholar
  79. A. Kannan, S.-N. M. Dodwad, and W. K. Hsu, “Biologics in spine arthrodesis,” Journal of Spinal Disorders & Techniques, vol. 28, no. 5, pp. 163–170, 2015. View at Publisher · View at Google Scholar · View at Scopus
  80. H. C. Pape, A. Evans, and P. Kobbe, “Autologous bone graft: properties and techniques,” Journal of Orthopaedic Trauma, vol. 24, supplement 1, pp. S36–S40, 2010. View at Publisher · View at Google Scholar · View at Scopus
  81. E. D. Arrington, W. J. Smith, H. G. Chambers, A. L. Bucknell, and N. A. Davino, “Complications of Iliac Crest Bone Graft Harvesting,” Clinical Orthopaedics & Related Research, vol. 329, pp. 300–309, 1996. View at Publisher · View at Google Scholar
  82. C. E. Schwartz, J. F. Martha, P. Kowalski et al., “Prospective evaluation of chronic pain associated with posterior autologous iliac crest bone graft harvest and its effect on postoperative outcome,” Health and Quality of Life Outcomes, vol. 7, article 49, 2009. View at Publisher · View at Google Scholar · View at Scopus
  83. M. Khashan, S. Inoue, and S. H. Berven, “Cell based therapies as compared to autologous bone grafts for spinal arthrodesis,” The Spine Journal, vol. 38, no. 21, pp. 1885–1891, 2013. View at Publisher · View at Google Scholar · View at Scopus
  84. R. M. Ajiboye, J. T. Hamamoto, M. A. Eckardt, and J. C. Wang, “Clinical and radiographic outcomes of concentrated bone marrow aspirate with allograft and demineralized bone matrix for posterolateral and interbody lumbar fusion in elderly patients,” European Spine Journal, vol. 24, no. 11, pp. 2567–2572, 2015. View at Publisher · View at Google Scholar · View at Scopus
  85. G. F. Muschler, H. Nitto, C. A. Boehm, and K. A. Easley, “Age- and gender-related changes in the cellularity of human bone marrow and the prevalence of osteoblastic progenitors,” Journal of Orthopaedic Research, vol. 19, no. 1, pp. 117–125, 2001. View at Publisher · View at Google Scholar · View at Scopus
  86. S. M. Mueller and J. Glowacki, “Age-related decline in the osteogenic potential of human bone marrow cells cultured in three-dimensional collagen sponges,” Journal of Cellular Biochemistry, vol. 82, no. 4, pp. 583–590, 2001. View at Publisher · View at Google Scholar · View at Scopus
  87. W. B. Rodgers, J. A. Lehmen, E. J. Gerber, and J. A. Rodgers, “Grade 2 spondylolisthesis at L4-5 treated by XLIF: Safety and midterm results in the worst case scenario,” The Scientific World Journal, vol. 2012, Article ID 356712, 2012. View at Publisher · View at Google Scholar · View at Scopus
  88. V. Campana, G. Milano, E. Pagano et al., “Bone substitutes in orthopaedic surgery: from basic science to clinical practice,” Journal of Materials Science: Materials in Medicine, vol. 25, no. 10, pp. 2445–2461, 2014. View at Publisher · View at Google Scholar · View at Scopus
  89. G. Zimmermann and A. Moghaddam, “Allograft bone matrix versus synthetic bone graft substitutes,” Injury, vol. 42, no. 2, pp. S16–S21, 2011. View at Publisher · View at Google Scholar · View at Scopus
  90. T. T. Roberts and A. J. Rosenbaum, “Bone grafts, bone substitutes and orthobiologics the bridge between basic science and clinical advancements in fracture healing,” Organogenesis, vol. 8, no. 4, pp. 114–124, 2012. View at Publisher · View at Google Scholar · View at Scopus
  91. R. M. Duarte, P. Varanda, R. L. Reis, A. R. Duarte, and J. Correia-Pinto, “Biomaterials and Bioactive Agents in Spinal Fusion,” Tissue Engineering Part B: Reviews, vol. 23, no. 6, pp. 540–551, 2017. View at Publisher · View at Google Scholar
  92. E. Gruskin, B. A. Doll, F. W. Futrell, J. P. Schmitz, and J. O. Hollinger, “Demineralized bone matrix in bone repair: history and use,” Advanced Drug Delivery Reviews, vol. 64, no. 12, pp. 1063–1077, 2012. View at Publisher · View at Google Scholar · View at Scopus
  93. K. Tilkeridis, P. Touzopoulos, A. Ververidis, S. Christodoulou, K. Kazakos, and G. I. Drosos, “Use of demineralized bone matrix in spinal fusion,” World Journal of Orthopedics, vol. 5, no. 1, pp. 30–37, 2014. View at Publisher · View at Google Scholar · View at Scopus
  94. H. W. Bae, L. Zhao, L. E. A. Kanim, P. Wong, R. B. Delamarter, and E. G. Dawson, “Intervariability and intravariability of bone morphogenetic proteins in commercially available demineralized bone matrix products,” The Spine Journal, vol. 31, no. 12, pp. 1299–1306, 2006. View at Publisher · View at Google Scholar · View at Scopus
  95. A. Kadam, P. W. Millhouse, C. K. Kepler et al., “Bone substitutes and expanders in spine surgery: A review of their fusion efficacies,” International Journal of Spine Surgery, vol. 10, no. 2016, article no. 3033, 2016. View at Publisher · View at Google Scholar · View at Scopus
  96. J. Kang, H. An, A. Hilibrand, S. T. Yoon, E. Kavanagh, and S. Boden, “Grafton and local bone have comparable outcomes to iliac crest bone in instrumented single-level lumbar fusions,” The Spine Journal, vol. 37, no. 12, pp. 1083–1091, 2012. View at Publisher · View at Google Scholar · View at Scopus
  97. W. K. Hsu, M. S. Nickoli, J. C. Wang et al., “Improving the Clinical Evidence of Bone Graft Substitute Technology in Lumbar Spine Surgery,” Global Spine Journal, vol. 2, no. 4, pp. 239–248, 2012. View at Publisher · View at Google Scholar
  98. M. S. Nickoli and W. K. Hsu, “Ceramic-Based Bone Grafts as a Bone Grafts Extender for Lumbar Spine Arthrodesis: A Systematic Review,” Global Spine Journal, vol. 4, no. 3, pp. 211–216, 2014. View at Publisher · View at Google Scholar
  99. G. Grabowski and C. A. Cornett, “Bone graft and bone graft substitutes in spine surgery: Current concepts and controversies,” Journal of the American Academy of OrthopaedicSurgeons , vol. 21, no. 1, pp. 51–60, 2013. View at Publisher · View at Google Scholar · View at Scopus
  100. W. K. Hsu, C. L. Goldstein, M. F. Shamji et al., “Novel Osteobiologics and Biomaterials in the Treatment of Spinal Disorders,” Neurosurgery, vol. 80, no. 3, pp. S100–S107, 2017. View at Publisher · View at Google Scholar · View at Scopus
  101. S. Ebara and K. Nakayama, “Mechanism for the action of bone morphogenetic proteins and regulation of their activity,” The Spine Journal, vol. 27, no. 16, supplement 1, pp. S10–S15, 2002. View at Publisher · View at Google Scholar · View at Scopus
  102. K. L. Ong, M. L. Villarraga, E. Lau, L. Y. Carreon, S. M. Kurtz, and S. D. Glassman, “Off-label use of bone morphogenetic proteins in the United States using administrative data,” The Spine Journal, vol. 35, no. 19, pp. 1794–1800, 2010. View at Publisher · View at Google Scholar · View at Scopus
  103. A. Faundez, C. Tournier, M. Garcia, S. Aunoble, and J.-C. Le Huec, “Bone morphogenetic protein use in spine surgery—complications and outcomes: a systematic review,” International Orthopaedics, vol. 40, no. 6, pp. 1309–1319, 2016. View at Publisher · View at Google Scholar · View at Scopus
  104. K. Singh, S. V. Nandyala, A. Marquez-Lara et al., “Clinical sequelae after rhBMP-2 use in a minimally invasive transforaminal lumbar interbody fusion,” The Spine Journal, vol. 13, no. 9, pp. 1118–1125, 2013. View at Publisher · View at Google Scholar · View at Scopus
  105. E. J. Carragee, E. L. Hurwitz, and B. K. Weiner, “A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned,” The Spine Journal, vol. 11, pp. 471–491, 2011. View at Publisher · View at Google Scholar
  106. O. R. Oliveira, S. P. Martins, W. G. Lima, and M. M. Gomes, “The use of bone morphogenetic proteins (BMP) and pseudarthrosis, a literature review,” Revista Brasileira de Ortopedia (English Edition), vol. 52, no. 2, pp. 124–140, 2017. View at Publisher · View at Google Scholar
  107. C. P. Hofstetter, A. S. Hofer, and A. D. Levi, “Exploratory meta-analysis on dose-related efficacy and morbidity of bone morphogenetic protein in spinal arthrodesis surgery,” Journal of Neurosurgery: Spine, vol. 24, no. 3, pp. 457–475, 2016. View at Publisher · View at Google Scholar · View at Scopus
  108. M. C. Simmonds, J. V. E. Brown, M. K. Heirs et al., “Safety and effectiveness of recombinant human bone morphogenetic protein-2 for spinal fusion: a meta-analysis of individual-participant data,” Annals of Internal Medicine, vol. 158, no. 12, pp. 877–889, 2013. View at Publisher · View at Google Scholar · View at Scopus
  109. R. Fu et al., “Effectiveness and harms of recombinant human bone morphogenetic protein-2 in spine fusion: a systematic review and meta-analysis,” Annals of Internal Medicine, vol. 158, no. 12, pp. 890–902, 2013. View at Google Scholar
  110. G. S. Cooper and T. D. Kou, “Risk of cancer after lumbar fusion surgery with recombinant human bone morphogenic protein-2 (rh-BMP-2),” The Spine Journal, vol. 38, no. 21, pp. 1862–1868, 2013. View at Publisher · View at Google Scholar · View at Scopus
  111. M. P. Kelly, J. W. Savage, S. M. Bentzen, W. K. Hsu, S. A. Ellison, and P. A. Anderson, “Cancer risk from bone morphogenetic protein exposure in spinal arthrodesis,” Journal of Bone and Joint Surgery - American Volume, vol. 96, no. 17, pp. 1417–1422, 2014. View at Publisher · View at Google Scholar · View at Scopus
  112. A. Parajón, M. Alimi, R. Navarro-Ramirez et al., “Minimally invasive transforaminal lumbar interbody fusion: meta-analysis of the fusion rates. what is the optimal graft material?” Neurosurgery, vol. 81, no. 6, pp. 958–971, 2017. View at Publisher · View at Google Scholar