In Vivo Evaluation of the Combined Anticancer Effects of Cisplatin and SAHA in Nonsmall Cell Lung Carcinoma Using [¹⁸F]FAHA and [¹⁸F]FDG PET/CT Imaging

Figure 1

Schematic representation of the study protocol. Animals bearing tumor xenografts were divided to three groups and received intraperitoneal injections of 2 mg/kg cisplatin (Group A), 4 mg/kg cisplatin (Group B), or 4 mg/kg cisplatin with 300 mg/kg SAHA (Group C) (see Materials and Methods for details). PET/CT imaging was performed before and after drug administration. The tumors were excised for IHC after PET/CT imaging.