Research Article

In Vivo Evaluation of the Combined Anticancer Effects of Cisplatin and SAHA in Nonsmall Cell Lung Carcinoma Using [18F]FAHA and [18F]FDG PET/CT Imaging

Figure 3

Axial tumor [18F]FAHA (upper panel) and [18F] FDG (lower panel) imaging before and after drug administration. [18F]FAHA PET/CT images were summed over 10 min (20–30 min after [18F]FAHA injection). Cisplatin significantly increased [18F]FAHA radioactivity in H441 and PC14 xenograft tumors, and this effect was blocked by SAHA. [18F] FDG imaging at 45–55 min after injection. Tumor [18F] FDG accumulation decreased after administration of cisplatin, but increased after administration of cisplatin with SAHA.