Molecular Imaging

Functional Nucleic Acid-Based Probes for Biological Imaging


Publishing date
01 Jul 2023
Status
Closed
Submission deadline
17 Feb 2023

Lead Editor
Guest Editors

1Xi’an Jiaotong Univeristy, Xi’an, China

2Emory University, Atlanta, USA

3Sun Yat-Sen University, Guangzhou, China

This issue is now closed for submissions.

Functional Nucleic Acid-Based Probes for Biological Imaging

This issue is now closed for submissions.

Description

Biological imaging is an important technique in understanding the molecular events of organisms and monitoring various biological processes of organisms. Nucleic acids are vital biomolecules, featuring predictable base pairing, high programmability, excellent biocompatibility, and mechanical stability. At present, the combination of nucleic acid probes with synthetic biology, nanotechnology, photothermal mediation, and other means has achieved dynamic control, high temporal and spatial resolution, and high specificity of biological imaging of various biological processes and physicochemical molecules.

However, imaging many biological targets can be difficult due to low concentrations, discrete distribution, and high heterogeneity, so the increasing the sensitivity of nucleic acid probes for biological imaging and the higher selectivity of ultra-low abundance mutation recognition are still huge challenges. Therefore, nucleic acid probes with stronger contrast function and non-specific interactions need to be developed.

The purpose of this Special Issue is to improve the design of nucleic acid probes for biological imaging to achieve real-time, dynamic, accurate, and efficient imaging of biological targets. It is hoped that this will help achieve early diagnosis and targeted treatment of related diseases. Original research and review articles are welcome.

Potential topics include but are not limited to the following:

  • Design of high-sensitivity nucleic acid-based nanoprobes
  • Development of synthetic nucleic acid gene circuits
  • Quantitative imaging and kinetic modeling of nucleic acid probes
  • Nucleic acid-based probes for biosensing or bioimaging
  • Studies of the function and mechanisms of nucleic acid probes
  • Application of nucleic acid-based probes in disease diagnosis
  • Application of nucleic acid-based probes in targeted therapy

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