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Mathematical Problems in Engineering
Volume 2010, Article ID 627035, 18 pages
Research Article

Robust Control of Continuous Bioprocesses

Department of Mathematics, Bohai University, Jinzhou 121000, China

Received 25 March 2010; Revised 17 May 2010; Accepted 5 July 2010

Academic Editor: John Burns

Copyright © 2010 Gongxian Xu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This paper deals with robust control of continuous bioprocesses. According to the material balance equations of continuous bioprocesses, a uniform framework for mathematical modeling of this class of processes is first presented. Then a robust controller is designed by using the mixed sensitivity method for the biotechnology processes. The corresponding control objective is described as the development of a robust reference-tracking control structure with the best possible disturbance compensation, able to cope with variations in key process parameters. Finally, the proposed robust control strategy is applied to bio-dissimilation process of glycerol to 1, 3-propanediol. Simulation results are given which show that the designed robust controller makes the system have a favourable robust tracking performance.