Optimal Tolerance Design and Optimization for a Pharmaceutical Quality Characteristic

Table 5

ANOVA of the mean of t (𝜇_𝑡).

Predictor	Coef	SE Coef	𝑇		𝑃
Constant	1.5693	0.0417	37.63		0.000
𝑥1	0.0641	0.0276	2.32		0.043
𝑥2	0.0706	0.0276	2.55		0.029
𝑥3	0.0752	0.0276	2.72		0.022
𝑥1𝑥2	−0.0548	0.0361	−1.52		0.160
𝑥1𝑥3	0.2103	0.0361	5.82		0.000
𝑥2𝑥3	0.0476	0.0361	1.32		0.217
𝑥1𝑥1	−0.0289	0.0269	−1.08		0.307
𝑥2𝑥2	0.0572	0.0269	2.13		0.059
𝑥3𝑥3	−0.0844	0.0269	−3.14		0.011
𝑆=0.102261	𝑅^2 = 88.1%		𝑅^2 (adj) = 77.4%
Analysis of variance
Source	DF	SS	MS	𝐹	𝑃
Regression	9	0.77375	0.08597	8.22	0.001
Residual error	10	0.10457	0.01046
Total	19	0.87833