Optimal Tolerance Design and Optimization for a Pharmaceutical Quality Characteristic

Table 6

ANOVA of the variance of t (𝜎²_𝑡).

Predictor	Coef	SE Coef	𝑇		𝑃
Constant	0.0073	0.0003	19.34		0.000
𝑥1	0.0000	0.0002	0.11		0.917
𝑥2	−0.0003	0.0002	−1.37		0.201
𝑥3	0.0000	0.0002	0.29		0.776
𝑥1𝑥2	−0.0001	0.0003	−0.38		0.711
𝑥1𝑥3	−0.0011	0.0003	−3.43		0.006
𝑥2𝑥3	−0.0001	0.0003	−0.38		0.711
𝑥1𝑥1	−0.0003	0.0002	−1.26		0.237
𝑥2𝑥2	−0.0004	0.0002	−1.98		0.076
𝑥3𝑥3	0.0000	0.0002	0.19		0.853
𝑆=0.000926452	𝑅^2 = 65.9%		𝑅^2 (adj) = 35.3%
Analysis of variance
Source	DF	SS	MS	𝐹	𝑃
Regression	9	1.66169𝐸−05	1.84632𝐸−06	2.15	0.124
Residual error	10	8.58313𝐸−06	8.58313𝐸−07
Total	19	0.0000252