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Working Characteristics of a Mechanical Insufflation-Exsufflation Device
Secretions of ventilated patients must be cleared efficiently and timely; to improve the secretion clearance efficiency of an insufflation-exsufflation device (IL-IE device) and lay a foundation for the optimization of the IL-IE device, a mathematical model of the ventilation system with the IL-IE device is set up. Through the experimental and simulation research on the ventilation system, it can be concluded that, firstly, the mathematical model is proved to be authentic and reliable. Secondly, with the deposition of secretion or an increase in the respiratory compliance, the peak exsufflation airflow may be reduced. Thirdly, with a decrease in the suction pressure, the peak exsufflation airflow of the ventilated lung may rise proportionally, but the minimum pressure in the ventilated lung may descend proportionally. To improve the efficiency of the secretion clearance but not to injure the ventilated patient, the suction pressure can be elevated properly. Last, increasing the inspiratory positive airway pressure (IPAP) is a method to improve the secretion clearance efficiency. This research lays a foundation for improving the secretion clearance efficiency of the IL-IE device.
Mechanical ventilation is usually used to ventilate patients who cannot breathe adequately on their own [1–3]. Because of the establishment of artificial airway, the secretion in lungs may be stimulated, and cilium movements may be restrained, which may result in the deposition of secretions in patient’s airway [4, 5]. Coughing is a vital defense mechanism of the airway, and the secretions in the airway can be cleared by peek cough flows (PCFs).
However, as to the ventilated patients, especially in coma, the physiologic function of their epiglottis may be weakened or even lost and the peak cough flows may be severely decreased, and that may seriously depress cough effectiveness [6–8]. Moreover, due to the use of sedatives and muscle relaxants, coughing capacity of ventilated patients may be further diminished [9–11].
Deposition of secretions in a patient’s airway may cause a rise in the respiratory resistance, hypoventilation, respiratory failure, and aggravation of the patient’s hypoxia and carbon dioxide retention [12–14]. Moreover, secretions blocking airway may easily lead to reproduction of bacteria, which may result in the occurrence or aggravation of the pulmonary infection [15–17]. Last but not least, respiratory complications, due to the airway secretion deposition, are the causes of morbidity and mortality [18–20].
Therefore, in order to maintain airway patency, increase life expectancy, and prolong survival, secretions in ventilated patients must be cleared efficiently and timely [21–24].
Mechanical insufflation-exsufflation (MI-E), as a method for mechanical assisted coughing, can be usually utilized for secretion clearance [18, 25–29]. Its working principle is that, after a deep inspiration, air in a patient’s lungs is expelled out immediately and rapidly by a forced exsufflation. During the exsufflation process, high expiratory flow rate and a high expiratory pressure gradient are generated between the mouth and the alveoli . The PCFs of at least 2.7 L/s are required to move secretions up effectively.
Compared with catheter suction technology, the MI-E technology has many advantages:(1)it is noninvasive and well tolerated hemodynamically ;(2)it does not introduce pathogens into the lung parenchyma ;(3)it is more effective and efficient, as it can clear secretions from not only the right side but also the left side of the bronchial tree. Moreover, it can generate airflow from as deep as the 5th generation bronchi .
CoughAssist (Philips Respironics Inc., Murrysville, PA) is a typical MI-E device, and its clinical effects have been approved [18, 26]. However, when it is applied, the patient’s ongoing mechanical ventilation must be interrupted to attach the device to the patient, which may entail first disconnecting the patient from the ventilator. And that may result in the patient’s inhalation parameters and FiO2 significantly differing from those to which he had been titrated while on the ventilator, and the patient does not receive positive end-expiratory pressure (PEEP) at all. Furthermore, it is usually repeatedly disconnected and reconnected from the patient and the ventilator by nurses .
Considering the disadvantages of the CoughAssist, Be’eri and Eliezer proposed a new MI-E device, called IL-IE device (Innovent Medical Solutions, Jerusalem, Israel). Through clinical application, it was proved that the device can avoid the traumatic and hemodynamic side-effects of catheter suction, improve the efficiency of secretion clearance, reduce the risk of respiratory complications, save staffs’ time, and so on .
In this paper, to illustrate the working characteristics of the IL-IE device and improve its secretion clearance efficiency, a mathematical model of the ventilation system with an IL-IE device is set up.
Moreover, to verify the mathematical model and avoid the injury to real lungs, a prototype ventilation system of a lung simulator is proposed. On the basis of experimental and simulation study on the prototype system, its dynamic characteristics can be gotten and analyzed.
Last, influences of the key parameters of the ventilator system on the peak exsufflation flow are studied.
2. Introduction of the IL-IE Device and a Ventilation System with the Device
2.1. Introduction of the IL-IE Device
According to the working principle of the IL-IE device, its structure diagram can be illustrated in Figure 1. It comprises a controller, a setting unit, a monitor, a ventilator connecting port, a bump, solenoid valves, a pneumatically operated membrane valve, a flow sensor, and a pressure sensor.
The pump can generate compressed air and vacuum simultaneously, the compressed air is used to control the pneumatically operated membrane valve, and the vacuum is utilized for air suction from a ventilated patient’s lungs. The pneumatically operated membrane valve is used to connect/disconnect a ventilator or the pump with a ventilated patient. The flow sensor and pressure sensor are to detect the airflow and pressure in the airway.
The setting unit and monitor are used to set and monitor the working states of the IL-IE device. Based on the signal of the flow sensor and pressure sensor, the controller can judge the time to perform MI-E treatment and control the working states of the pump and the solenoid valve accordingly.
According to , the working principle of the IL-IE device is that the device can be connected in-line with the patient’s ventilation circuit and endotracheal (ET) tube via a disposable pneumatically operated membrane valve. The device performs MI-E treatments by initiating a sudden suction exsufflation immediately after the ventilator has completed an inspiration, in the following manner. The device monitors the pressure and airflow in the airway, identifies the onset of exhalation, commences high-flow suction at that time, and continues the suction until exsufflation airflow starts approaching zero. Throughout the duration of exsufflation, the membrane valve is activated, closing off the ventilation circuit so that the ventilator itself is not exposed to the exsufflation suction force at all. When exsufflation has terminated and the membrane valve deactivates, reexpose the ventilator to the patient and allow ongoing ventilation to continue uninterruptedly. A single treatment comprises several MI-E cycles in a row (typically 6). After the treatment, secretions which may have migrated up into the ET tube can be removed by performing shallow suction (confined to the ET tube) with an in-line suction catheter, if needed. The device can be programmed to perform MI-E treatments automatically at regular intervals (such as every 15 minutes) in an ongoing fashion and/or can be activated by a button pushed by the nurse or even by the patient, whenever desired. The system can work with both invasive ET tube ventilation and noninvasive facemask ventilation .
2.2. Introduction of a Ventilation System with the IL-IE Device
A simplified mechanical ventilation system with the IL-IE device, as illustrated in Figure 2(a), is composed of a human lung, some tubes, a ventilator, and an IL-IE device.
(a) Simplified mechanical ventilation system
(b) Equivalent pneumatic system
According to the main functions of ventilator and the IL-IE device, they can be considered as an air compressor and a vacuum pump, respectively.
In this simplified system, the respiratory resistances result from friction loss of the flexible tubes and the respiratory system (including respiratory airway and lung). Therefore, the tubes and the respiratory system of a comatose patient can be equivalent to two combinations of a throttle and a volume variable container, and then the total resistances are represented by the friction losses of the two equivalent throttles.
Because the lengths of the inspiration circuit and the expiration circuit are almost fixed, the structure parameters of the two equivalent combinations, which affect the respiratory resistance, are just their effective areas (, ) of the two equivalent throttles.
As the pressure of ventilation system is almost −40 cm H2O ~ 40 cm H2O, compliances of the tubes can be neglected [32–34].
Therefore, the simplified mechanical ventilation system can be regarded as a pure pneumatic system, as shown in Figure 2(b). The compressor, the vacuum pump, combination , and combination represent the ventilator, the IL-IE device, the flexible tube, and the respiratory system, respectively.
3. Simulation and Experimental Study on the Mechanical Ventilation System
3.1. Modeling of Mechanical Ventilation System
3.1.1. Flow Equation of the Lung Simulator
When air flows through throttle, its mass flow can be calculated by the equation when air flows through the LAVAL nozzle. As the pressure of the studied ventilation system is about −40 cm H2O ~ 40 cm H2O, therefore, is always bigger than (0.528); then, the mass flow equation of each throttle in the ventilation system can be obtained as follows: where is flow coefficient; it is 1 when air flows into a chamber. Inversely, it is −1 when air exhausts from a chamber.
In the standard reference atmosphere state, the volume flow of air can be calculated by the following equation:
3.1.2. Pressure Equation
The ventilation system can be considered as an open thermodynamic system, and its working can be regarded as an isothermal process. The pressure in the containers in the system can be calculated by the differential expression of Clapeyron equation , which can be given as
In this study, the ventilation model is BiPAP and time-triggered. Therefore, in a normal ventilation cycle, the output pressure of the ventilator can be given as
When the secretion should be cleared, the output pressure of the IL-IE device can be defined as the suction pressure ().
3.1.3. Volume Equation
According to the definition of compliance , the compliance of containers and can be described as 
Then, the volume of containers and can be calculated by the following formulas:
3.2. Validation of the Mathematical Model
3.2.1. Experimental Apparatus
As in the above discussion, when the suction pressure of the IL-IE device is set the same as the expiatory positive airway pressure (EPAP), the exsufflation process of the IL-IE device is equal to a normal expiration process of a ventilator. Therefore, the exsufflation process can be considered as a special expiration process of the ventilation system.
To verify the mathematical model and avoid the injury to real lungs, an experimental ventilation system of a lung simulator is proposed, as shown in Figure 3, which consists of a BiPAP ventilator by Philips Respironics, a tube, an Air Power Meter (combines a flow sensor and a pressure sensor) by Tokyo Meter, a lung simulator by VADI, a data acquisition card by Advantech, and a computer by Lenovo. The adopted Air Power Meter (APM-450) can measure the flow, pressure, and temperature of air simultaneously. The uncertainty of the pressure, flow, and temperature is 0.1%, ±1% F.S., and 0.10 C, respectively [36–38].
3.2.2. Experimental and Simulation Study on the Ventilation System
The values of the ventilator settings, including inspiratory positive airway pressure (IPAP), EPAP, breaths per minute (BPM), inspiratory time (), and rise time () of pressure, are set at 22 cm H2O, 4 cm H2O, 20, 1.2 s, and 0.3 s, respectively. The diameter of the tube is 22 mm, the inlet diameter of lung simulator is 3.2 mm, and, therefore, the effective areas of the equivalent throttles and are 380 mm2 and 8 mm2.
The fluctuation amplitude of airflow and pressure is so high and the frequency is so high that wavelet filter technology was adopted in this study. Through the experiment, it can be calculated that the compliance of the lung simulator is about 5 mL/cm H2O.
The initial values of the parameters in the simulation study are the same as the values in the experimental study. The software Matlab/simulink is used for simulation.
The experimental pressure () in the tube, the simulation pressure () in the tube, and the simulation pressure () in the lung simulator are shown in Figure 4. The airflows of the respiratory system, which are obtained by experimentation and simulation, are shown in Figure 5.
From Figures 4 and 5, it can be gotten that(1)as the average IPAP and EPAP, in the report of the ventilator, are 21.3 cm H2O and 3.9 cm H2O, respectively, hence, the measured data are consistent with the ventilator report, and the experiment results are authentic and reliable;(2)the simulation results have a good consistency with the experimental results, and this verifies the mathematical model above;(3)as can be seen, the air pressure in the lung simulator always lags behind the output pressure of the ventilator. The main reason is that the respiratory resistance and compliance block the increasing and decreasing of the air pressure in the lung simulator.
Therefore, the mathematical model can be used in the study on the ventilation system with the IL-IE device.
4. Study on the Dynamics of the Ventilation System with the IL-IE Device
4.1. Dynamics of the Ventilation System
As the compliance of the ventilated lung is set at 50 mL/cm H2O, the inner diameters of the tube and the endotracheal intubation are set at 10 mm and 7 mm. The IPAP, EPAP, and suction pressure are set at 4 cm H2O, 22 cm H2O, and −30 cm H2O, respectively. When exsufflation flow is less than 2.7 L/s, the exsufflation process is terminated.
The curves of six pressures (namely, the output pressure () of the ventilator in the ventilation process, the output pressure () of the IL-IE device in the secretion clearance process, the pressure () in the tube in the ventilation process, the pressure () in the tube in the secretion clearance process, the pressure () in the ventilated lung in the ventilation process, and the pressure () in the ventilated lung in the secretion clearance process) are shown in Figure 6. The airflow () of the ventilated lung in the ventilation process and the airflow () of the ventilated lung in the secretion clearance process are shown in Figure 7.
As illustrated in Figures 6 and 7, the dynamic characteristics of the system during secretion clearance process can be seen.
Due to the respiratory resistance and the compliance, with a growth or a descent in the pressure in the tube, the pressure in the ventilated lung ascends or declines accordingly.
The pressure in the ventilated lung declines faster in the secretion clearance process than in the expiration process. At the end of the exsufflation process, the pressure in the ventilated lung is a little lower than the EPAP, which may harm the patient’s respiratory system.
After the exsufflation process, to maintain the EPAP of the ventilation system, the ventilator continues to transfer air to the ventilated lung, and then the pressures in the tube and the lung start to increase to the EPAP.
4.2. Influence of the key Parameters on the Dynamics of the Ventilation System
According to , to clear secretions effectively, the peak exsufflation airflow should be larger than 2.7 L/s. In order to improve the secretion clearance efficiency of the device, influences of some key parameters (such as the settings of the ventilator, the suction pressure, and the respiratory parameters of the ventilation system) on the dynamics of the ventilation system should be studied.
4.2.1. Influence of the Suction Pressure on the Dynamics
The influences of the suction pressure on the dynamic characteristics of the ventilation system are shown in Figures 8, 9, and 10.
As illustrated in Figures 8, 9, and 10, it can be seen that
the peak exsufflation airflow is negatively proportional to the suction pressure. When the suction pressure is lower than −35 cm H2O, the minimum pressure in the ventilated lung increases proportionally with a growth in the suction pressure. However, when the suction pressure is higher than −35 cm H2O, the minimum pressure in the ventilated lung may be higher than the EPAP.
Therefore, decreasing the suction pressure can improve the peak exsufflation airflow. But if the suction pressure is set too low, the minimum pressure in the lung may get lower than the EPAP, and that may injure the patient’s respiratory system.
4.2.2. Influences of the Effective Area of the Respiratory Airway on the Dynamics
The influences of the effective area () of the respiratory airway on the dynamics are depicted in Figures 11, 12, and 13.
As shown in Figures 11, 12, and 13, with a rise in the effective area , the peak exsufflation airflow of the ventilated lung may ascend. When the effective area is bigger than 40 mm2, the minimum pressure in the ventilated lung may decrease with a rise in the effective area . However, the effective area is smaller than 40 mm2; the minimum pressure in the ventilated lung may be higher than the EPAP.
Therefore, if the effective area gets too small, the peak exsufflation airflow may not reach 2.7 L/s. However, if the effective area is too large, the minimum pressure in the lung may drop substantially, which may impair the patient’s respiratory system.
4.2.3. Influences of the Respiratory Compliance on the Dynamics
The influences of the respiratory compliance on the dynamics are depicted in Figures 14 and 15.
It can be seen that the minimum pressure in the lung is hardly influenced by the respiratory compliance. However, when the respiratory compliance is bigger than 5 mL/cm H2O, the peak exsufflation airflow descends with an increase in the respiratory compliance. When the respiratory compliance is smaller than 5 mL/cm H2O, the peak exsufflation airflow almost remains the same.
Therefore, with the deposition of the secretion in the respiratory airway, its effective area may be narrowed, and then the peak exsufflation airflow may be reduced. With an increase in the respiratory compliance, the peak exsufflation airflow may be reduced. To ensure the secretion clearance efficiency, the suction pressure must be elevated properly.
4.2.4. Influences of the Ventilator Settings on the Dynamics
The influences of the IPAP and EPAP on the dynamics are shown in Figures 16 and 17.
From Figures 16 and 17, it can be seen that
increasing the IPAP can improve the peak exsufflation airflow and prolong the exsufflation duration. However, the exsufflation airflow dynamics are hardly influenced by the EPAP.
Therefore, increasing the IPAP is a method to improve the secretion clearance efficiency, though the IPAP can be adjusted by the IL-IE automatically.
In this research, to improve the secretion clearance efficiency and lay a foundation for the optimization of the IL-IE device, the mathematical model of the secretion clearance system is set up. Through the research on the ventilation system, it can be concluded that(1)the experimental and the simulation results are authentic and reliable, and the mathematical model can be used in the study on the ventilation system with the IL-IE device;(2)with a decrease in the suction pressure, the peak exsufflation airflow of the ventilated lung may rise proportionally, but the minimum pressure in the ventilated lung may almost descend proportionally. To improve the efficiency of the secretion clearance, the suction pressure can be elevated properly;(3)with the deposition of secretion or a growth in respiratory compliance, the peak exsufflation airflow may be reduced. To ensure the secretion clearance efficiency, the suction pressure must be elevated appropriately;(4)increasing the IPAP is a method to improve the secretion clearance efficiency, though the IPAP can be adjusted by the IL-IE.
|:||Equivalent effective area [m2]|
|:||Critical pressure ratio = 0.5283|
|:||Respiratory compliance [L/cmH2O]|
|:||Diameter of equivalent effective area [m]|
|:||Mass of air [kg]|
|:||Coefficient of proportionality|
|:||Air mass flow [kg/s]|
|:||Air volume flow [m3/s]|
|:||Gas constant = 287 [J/(kgK)]|
|:||Specific heat ratio = 1.4|
|:||The standard reference atmosphere state|
|:||Flow of air|
|epap:||Expiatory positive airway pressure|
|il-ie:||The IL-IE device|
|ipap:||Inspiratory positive airway pressure|
|:||Pressure rising time|
|:||Suction process/exsufflation process|
|:||Ventilator or ventilation process.|
Conflict of Interests
The authors declare that there is no conflict of interests regarding the publication of this paper.
The research is funded by Open Foundation of the State Key Laboratory of Fluid Power Transmission and Control.
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