Study on Optimal Generative Network for Synthesizing Brain Tumor-Segmented MR Images

<div>CycleGAN with mapping functions <svg height="8.98583pt" id="M4" style="vertical-align:-0.2324905pt" version="1.1" viewbox="-0.0498162 -8.75334 64.1693 8.98583" width="64.1693pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M692 302H438V274C537 267 543 260 543 188V103C543 61 531 48 511 37C489 26 458 20 424 20C231 20 146 188 146 333C146 517 258 630 411 630C507 630 582 597 606 474L634 480C627 546 622 601 619 636C586 643 510 665 426 665C230 665 44 552 44 321C44 122 191 -15 411 -15C491 -15 573 7 635 21C629 49 628 81 628 116V202C628 261 632 266 692 274V302Z"></path></g><g transform="matrix(.013,0,0,-0.013,12.962,0)"><path d="M116 412C83 412 59 388 59 355C59 321 83 297 115 297S170 321 170 355C170 388 147 412 116 412ZM114 -12C147 -12 171 11 171 46C171 78 147 103 115 103C84 103 60 78 60 46C60 11 84 -12 114 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,19.558,0)"><path d="M655 0V28C585 35 563 50 517 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412 456 470 501 543C539 604 551 614 620 622V650Z"></path></g></svg> and <span class="nowrap"><svg height="8.73137pt" id="M5" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -8.52498 61.7422 8.73137" width="61.7422pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M493 503C489 551 484 614 483 650H43V622C120 616 128 611 128 525V126C128 40 120 34 40 28V0H312V28C221 34 213 40 213 126V307H316C407 307 412 296 424 227H453V420H424C412 355 407 346 316 346H213V584C213 613 216 616 246 616H322C398 616 419 607 436 579C449 559 455 539 464 499L493 503Z"></path></g><g transform="matrix(.013,0,0,-0.013,10.535,0)"><path d="M116 412C83 412 59 388 59 355C59 321 83 297 115 297S170 321 170 355C170 388 147 412 116 412ZM114 -12C147 -12 171 11 171 46C171 78 147 103 115 103C84 103 60 78 60 46C60 11 84 -12 114 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,17.13,0)"><path d="M620 650H399V622C477 614 480 606 457 556C429 495 375 397 338 331C295 406 246 488 203 568C185 601 182 613 254 622V650H15V622C75 617 86 606 126 537C180 445 217 379 252 318C269 287 273 278 273 258V125C273 40 265 34 176 28V0H458V28C366 34 358 41 358 125V261C358 287 361 298 375 324C422 412 456 470 501 543C539 604 551 614 620 622V650Z"></path></g><g transform="matrix(.013,0,0,-0.013,31.21,0)"><path d="M567 230V280H69V230H567Z"></path></g><g transform="matrix(.013,0,0,-0.013,36.986,0)"><path d="M901 255C861 290 790 361 716 442L694 427L796 280H69V230H796L694 83L716 68C790 149 861 220 901 255Z"></path></g><g transform="matrix(.013,0,0,-0.013,53.098,0)"><path d="M655 0V28C585 35 563 50 517 120C469 193 414 280 360 366C427 469 460 516 481 545C526 604 545 614 619 622V650H391V622C457 614 462 604 438 560C411 511 381 463 339 398C295 466 258 523 225 580C210 606 211 615 272 622V650H26V622C98 614 111 603 154 538C189 482 235 408 288 324C200 188 149 116 124 85C95 47 64 34 7 28V0H236V28C169 36 164 46 188 89C220 148 261 217 310 291C372 193 417 118 442 77C461 44 454 35 392 28V0H655Z"></path></g></svg>,</span> and associated adversarial discriminators <svg height="11.8174pt" id="M6" style="vertical-align:-3.1815pt" version="1.1" viewbox="-0.0498162 -8.6359 16.5837 11.8174" width="16.5837pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M743 375C743 570 607 650 407 650H136L130 622C214 612 220 606 204 526L125 122C110 43 105 36 24 27L17 0H250C382 0 482 23 571 76C680 141 743 248 743 375ZM644 379C644 188 520 36 305 36C277 36 249 38 229 46C205 55 202 71 212 126L293 553C300 588 306 600 317 606C330 613 356 617 390 617C547 617 644 537 644 379Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,9.893,3.132)"><path d="M679 650H432L424 619L456 615C499 610 507 601 486 568C442 499 366 400 315 336C281 403 229 526 211 570C199 600 202 610 239 614C239 614 281 618 281 619L288 650H33L24 619C98 612 106 606 129 552L226 325C238 297 238 282 234 259L211 136C193 42 184 38 97 32L86 0H375L382 32C285 39 277 45 296 136L324 267C329 290 337 304 350 322C420 416 479 489 523 539C582 607 595 613 668 619L679 650Z"></path></g></svg> and <span class="nowrap"><svg height="11.8174pt" id="M7" style="vertical-align:-3.1815pt" version="1.1" viewbox="-0.0498162 -8.6359 17.5885 11.8174" width="17.5885pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M743 375C743 570 607 650 407 650H136L130 622C214 612 220 606 204 526L125 122C110 43 105 36 24 27L17 0H250C382 0 482 23 571 76C680 141 743 248 743 375ZM644 379C644 188 520 36 305 36C277 36 249 38 229 46C205 55 202 71 212 126L293 553C300 588 306 600 317 606C330 613 356 617 390 617C547 617 644 537 644 379Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,9.893,3.132)"><path d="M782 650H541L536 618L564 614C597 609 604 600 584 574C535 508 486 451 437 395C394 473 361 533 343 575C331 605 335 610 375 615L400 618L407 650H156L147 618C222 612 230 608 267 537L375 330C277 214 186 117 163 96C108 43 97 38 27 32L18 0H265L274 32L251 35C204 41 202 47 224 80C264 138 327 213 397 293L504 80C520 48 516 42 472 36L440 32L433 0H707L716 32C627 38 622 43 581 121L455 361L629 548C685 606 696 610 775 618L782 650Z"></path></g></svg>.</span> Forward cycle-consistency loss (red): <span class="nowrap"><svg height="14.1923pt" id="M8" style="vertical-align:-2.2681pt" version="1.1" viewbox="-0.0498162 -11.9242 162.998 14.1923" width="162.998pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M655 0V28C585 35 563 50 517 120C469 193 414 280 360 366C427 469 460 516 481 545C526 604 545 614 619 622V650H391V622C457 614 462 604 438 560C411 511 381 463 339 398C295 466 258 523 225 580C210 606 211 615 272 622V650H26V622C98 614 111 603 154 538C189 482 235 408 288 324C200 188 149 116 124 85C95 47 64 34 7 28V0H236V28C169 36 164 46 188 89C220 148 261 217 310 291C372 193 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79 382 50 340L81 307C101 339 134 364 172 364C198 364 245 343 280 326C324 305 375 283 417 283C466 283 507 314 537 353ZM537 168L508 205C487 172 455 148 417 148C389 148 344 168 309 185C265 206 212 229 172 229C122 229 79 197 50 155L81 122C101 154 134 179 172 179C198 179 245 158 280 141C324 120 375 98 417 98C466 98 507 129 537 168Z"></path></g><g transform="matrix(.013,0,0,-0.013,154.202,-2.897)"><path d="M658 557C549 593 437 629 340 673H318C222 629 109 593 0 557L9 532C116 551 225 577 329 602C435 576 543 551 649 532L658 557Z"></path></g><g transform="matrix(.013,0,0,-0.013,152.786,0)"><path d="M748 650H522L515 622L546 617C580 611 587 604 565 575C518 513 469 451 419 393C376 474 349 534 330 580C318 609 325 612 361 618L383 622L392 650H151L144 622C214 616 224 612 257 543L360 327C270 218 187 124 159 95C106 40 92 34 26 28L17 0H252L259 28L236 31C189 37 188 47 209 78C249 136 308 210 377 294L478 79C494 44 487 37 449 32L418 28L409 0H673L680 28C596 34 591 39 554 116L436 361C526 469 574 521 604 553C659 612 669 614 739 622L748 650Z"></path></g></svg>,</span> and backward cycle-consistency loss (blue): <span class="nowrap"><svg height="14.1923pt" id="M9" style="vertical-align:-2.2681pt" version="1.1" viewbox="-0.0498162 -11.9242 158.313 14.1923" width="158.313pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M620 650H399V622C477 614 480 606 457 556C429 495 375 397 338 331C295 406 246 488 203 568C185 601 182 613 254 622V650H15V622C75 617 86 606 126 537C180 445 217 379 252 318C269 287 273 278 273 258V125C273 40 265 34 176 28V0H458V28C366 34 358 41 358 125V261C358 287 361 298 375 324C422 412 456 470 501 543C539 604 551 614 620 622V650Z"></path></g><g transform="matrix(.013,0,0,-0.013,14.08,0)"><path d="M567 230V280H69V230H567Z"></path></g><g transform="matrix(.013,0,0,-0.013,19.856,0)"><path d="M901 255C861 290 790 361 716 442L694 427L796 280H69V230H796L694 83L716 68C790 149 861 220 901 255Z"></path></g><g transform="matrix(.013,0,0,-0.013,35.967,0)"><path d="M493 503C489 551 484 614 483 650H43V622C120 616 128 611 128 525V126C128 40 120 34 40 28V0H312V28C221 34 213 40 213 126V307H316C407 307 412 296 424 227H453V420H424C412 355 407 346 316 346H213V584C213 613 216 616 246 616H322C398 616 419 607 436 579C449 559 455 539 464 499L493 503Z"></path></g><g transform="matrix(.013,0,0,-0.013,42.87,0)"><path d="M300 -147C201 -63 143 98 143 270S200 602 300 686L282 710C136 610 70 450 70 271V270C70 89 136 -72 282 -170L300 -147Z"></path></g><g transform="matrix(.013,0,0,-0.013,47.368,0)"><path d="M620 650H399V622C477 614 480 606 457 556C429 495 375 397 338 331C295 406 246 488 203 568C185 601 182 613 254 622V650H15V622C75 617 86 606 126 537C180 445 217 379 252 318C269 287 273 278 273 258V125C273 40 265 34 176 28V0H458V28C366 34 358 41 358 125V261C358 287 361 298 375 324C422 412 456 470 501 543C539 604 551 614 620 622V650Z"></path></g><g transform="matrix(.013,0,0,-0.013,55.641,0)"><path d="M275 270C275 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Mathematical Problems in Engineering

fig4

Figure 4

Figure 4: Study on Optimal Generative Network for Synthesizing Brain Tumor-Segmented MR Images 