Review Article

Emerging Patent Landscape for Gene Therapy as a Potential Cure for COVID-19

Table 2

Gene therapy-related patents for SARS and MERS.

Publication numberApplication dateOrganizationVirus/mechanismGene targets/vectors

WO2017044507A22016/9/7Sirnaomics Inc.MERS-CoV; siRNAPLpro, RdRp, S protein; polymeric nanoparticle, liposomal nanoparticle
CN102453712A2010/10/19Chinese Academy of Medical SciencesSARS-CoV; siRNAPI4KB; adenovirus; VeroE6 cell
CN101597607A2005/3/25Chinese Academy of Medical SciencesSARS-CoV; siRNAN protein; pCMV-Myc
CN101173275A2006/10/31Chinese Academy of Medical SciencesSARS-CoV; siRNAM protein
CN101113158A2006/12/18Sichuan UniversitySARS-CoV; siRNARdRp; plasmid
CN101085986A2006/6/8Shanghai Institutes for Biological Sciences, CASSARS-CoV; siRNAORF3a
WO2006130855A22006/6/1California Institute of TechnologySARS-CoVRecombinant retrovirus
CN1704123A2004/6/1Guangzhou Tuopu Genetech Ltd.SARS-CoV; siRNACationic polymers, peptides
CN1648249A2004/1/19Shanghai Institutes for Biological Sciences, CASSARS-CoV; siRNA19–25 consecutive nucleic acids on the M, N, and E genes
US20050095618A12004/7/28Chinese University of Hong KongSARS-CoV; siRNAS protein
WO2005019410A22004/4/26Intradigm CorporationSARS-CoV; dsRNAnsp1, nsp9, S; aqueous glucose solution
WO2004092383A22004/4/13Sirna Therapeutics, Inc.siRNA, dsRNA, miRNA, shRNAChemically synthesized, modulate the expression of SARS virus RNA
US20140294752A12014/4/1Research & Business FDN Sungkyunkwan Univ.Hyaluronic acid conjugateTo deliver RNA, DNA, siRNA, aptamer, antisense oligodeoxynucleotide, antisense RNA, ribozyme, DNAzyme
WO2014144486A22014/3/14Children’s Hospital of PhiladelphiaRecombinant vector plasmidCell, viral particle, and AAV particle comprising the recombinant vector plasmid
WO2013123503A12013/2/19Children’s Hospital of PhiladelphiaAAV-Rh74 vector for gene transferAAV vector comprising a heterologous polynucleotide
WO2010111522A22010/3/25University of CaliforniaMesenchymal stem cellFor delivery of siRNA, miRNA, or dsRNA polynucleotide into a target cell
WO2010054266A22009/11/6University of WashingtonMultiblock copolymersFor delivery of siRNA, antisense oligonucleotide, dicer substrate, miRNA, aiRNA, shRNA, or siRNA

Note. Listing items include the virus and the targeting gene, mechanism, and gene delivery vectors.