Additive In Vitro Antiplasmodial Effect of N-Alkyl and N-Benzyl-1,10-Phenanthroline Derivatives and Cysteine Protease Inhibitor E64

Table 1

In vitro antiplasmodial activity of N-alkyl and N-benzyl-1-10 phenanthroline derivatives, chloroquine diphosphate and E64 against P. falciparum FCR3.

Compound	Mean IC50 (nM) ± SD
(1)-N-methyl-1,10-phenanthrolinium sulfate	260 ± 40
(1)-N-ethyl-1,10-phenanthrolinium sulfate	465 ± 57
(1)-N-benzyl-1,10-phenanthrolinium chloride	328 ± 44
(1)-N-benzyl-1,10-phenanthrolinium iodide	273 ± 27
Chloroquine diphosphate	24 ± 3
E64	836 ± 13