Malaria Research and Treatment / 2011 / Article / Tab 1

Research Article

Plasmodium falciparum: Assessment of Selectivity of Action of Chloroquine, Alchornea cordifolia, Ficus polita, and Other Drugs by a Tetrazolium-Based Colorimetric Assay

Table 1

Effects of drugs and plant extracts against P. falciparum strains DD2 (A) and 3D7 (B) infection in RBCs.

DrugEC50  μg/mLEC90  μg/mLCC50  μg/mLSI (CC50/EC50)

(A)Sigma CQa*10.020.4NANA
Sigma CQb*21.077.982.73.9
Formulated CQb32.6>50c>50c>1.5
GHX-6Lb>445c>445c>445cND
GHX-26Fb272.8>340c>340c>1.2
(B)Formulated CQb0.0250.05>50c>2,000
GHX-6Lb>445c>445c>445cND
GHX-26Fb4.916.2>340c>69.4

aTested by IMT, bTested by MTT-based CSA, *Parasitemia used was 1.5%. For the other tests, parasitemia used was 3.0%, cHighest concentration tested, SI: selective index, NA: not applicable, ND: not determined.

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