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Malaria Research and Treatment
Volume 2013 (2013), Article ID 310246, 11 pages
Research Article

Selective Intermittent Preventive Treatment of Vivax Malaria: Reduction of Malaria Incidence in an Open Cohort Study in Brazilian Amazon

1Instituto de Pesquisas em Patologias Tropicais (IPEPATRO), Rua da Beira, 7671, Bairro Lagoa, 76.812-245 Porto Velho, RO, Brazil
2Fundação Oswaldo Cruz (FIOCRUZ Rondônia), Rua da Beira, 7671, Bairro Lagoa, 76.812-245 Porto Velho, RO, Brazil
3Centro de Pesquisa em Patologias Tropicais (CEPEM/SESAU), Av. Guaporé, 215, Bairro Lagoa, Porto Velho, RO, Brazil
4Universidade Federal de Rondônia (UNIR), Núcleo de Saúde, NUSAU, Campus BR 364, km 9,5, Porto Velho, RO, Brazil
5Universidade Federal de Mato Grosso (UFMT), Núcleo de Estudos de Doenças Infecciosas e Tropicais de Mato Grosso, Rua Luiz Phellipe Pereira Leite s/n, Alvorada, Cuiabá, MT, Brazil

Received 11 December 2012; Revised 11 February 2013; Accepted 19 February 2013

Academic Editor: Mats Wahlgren

Copyright © 2013 Tony Hiroshi Katsuragawa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In children, the Intermittent Preventive Treatment (IPTc), currently called Seasonal Malaria Chemoprevention (SMC), was considered effective on malaria control due to the reduction of its incidence in Papua New Guinea and in some areas with seasonal malaria in Africa. However, the IPT has not been indicated because of its association with drug resistance and for hindering natural immunity development. Thus, we evaluated the alternative IPT impact on malaria incidence in three riverside communities on Madeira River, in the municipality of Porto Velho, RO. We denominate this scheme Selective Intermittent Preventive Treatment (SIPT). The SIPT consists in a weekly dose of two 150 mg chloroquine tablets for 12 weeks, for adults, and an equivalent dose for children, after complete supervised treatment for P. vivax infection. This scheme is recommend by Brazilian Health Ministry to avoid frequent relapses. The clinic parasitological and epidemiological surveillance showed a significant reduction on vivax malaria incidence. The results showed a reduction on relapses and recurrence of malaria after SIPT implementation. The SIPT can be effective on vivax malaria control in localities with high transmission risk in the Brazilian Amazon.