Exploiting Unique Structural and Functional Properties of Malarial Glycolytic Enzymes for Antimalarial Drug Development

Table 2

Percent identity and percent similarity of P. falciparum glycolytic enzymes with their major human homologs. Percent identity and percent similarity were calculated by alignment of sequences using National Center for Biotechnology Information’s BLAST server (http://blast.ncbi.nlm.nih.gov/Blast.cgi/).

P. falciparum enzyme	Human homolog	Percent identity	Percent similarity	-value
Hexokinase (PfHK)	Hexokinase, isoform 2 (erythrocyte)	32	50	(residues 9–458), (residues 461–906)
Glucose 6-phosphate isomerase (PfGPI)	Glucose 6-phosphate isomerase, isoform 2	32	52	(residues 53–543), 4.5 (residues 518–543)
Phosphofructokinase 9 (PfPFK9)	6-Phosphofructokinase, muscle type, isoform 1	26	39	(residues 18–232), (residues 459–635), (residues 377 to 574), 0.65 (residues 296 to 341)
Phosphofructokinase 11 (PfPFK11)	6-Phosphofructokinase, muscle type, isoform 1	27	41	0.022 (residues 438–497)
Aldolase (PfALDO)	Aldolase A	54	66	(residues 2–364)
Triosephosphate isomerase (PfTPI)	Triosephosphate isomerase, isoform 2	43	60	(residues 4–247)
Glyceraldehyde 3-phosphate dehydrogenase (PfGAPDH)	GAPDH isoform 1, liver-specific	64	77	(residues 1 to 333)
Phosphoglycerate kinase (PfPGK)	Phosphoglycerate kinase isoform 1	61	76	0.0 (residues 3–416)
Phosphoglycerate mutase 1 (PfPGM1)	Phosphoglycerate mutase 1	56	72	(residues 1 to 253)
Phosphoglycerate mutase 2 (PfPGM2)	Phosphoglycerate mutase 2	26	51	0.019 (residues 2–66)
Enolase (PfENO)	Alpha enolase	67	79	0.0 (residues 3–429)
Pyruvate kinase 1 (PfPK1)	Pyruvate kinase L, R	45	61	(residues 75–573)
Pyruvate kinase 2 (PfPK2)	Pyruvate kinase L, R	30	49	(residues 301–556), (residues 91–302)
Lactate dehydrogenase (PfLDH)	LDH-A	29	54	(residues 70–368)