Occurrence of pfatpase6 Single Nucleotide Polymorphisms Associated with Artemisinin Resistance among Field Isolates of Plasmodium falciparum in North-Eastern Tanzania

Table 3

Analyses for statistical change of pfatpase6 SNPs frequencies from 2010 to 2013.

SNP	Measure	2010	2011	2013
L263E	%	0.0	3.9	2.6
		0^*	6^*	4
	95% CI	0.0–3.0	1.6–8.7	0.8–6.9
E431K	%	16.9	10.4	13
		26	16	20
	95% CI	11.5–23.9	6.2–16.6	8.3–19.6
A623E	%	0.0	0.0	0.0
		0	0	0
	95% CI	0.0–3.0	0.0–3.0	0.0–3.0
S769N	%	2.0	3.9	5.2
		3	6	8
	95% CI	0.5–6.1	1.6–8.7	2.4–10.3

Fisher’s exact test revealed a significant change between the two points ().
Combined, the frequency change of L263E and S769N over the three years was statistically significant by Fisher’s exact test ().