A Pharmacokinetic Study of Antimalarial 3,5-Diaryl-2-aminopyridine Derivatives

Table 2

Pharmacokinetic parameters of 3,5-diaryl-2-aminopyridine compounds after oral and intravenous administration. Data represent mean ± standard deviation of data points obtained from five mice.

Parameters	Compound 1		Compound 2
	Oral	IV	Oral	IV
(hours)	2.53 ± 0.1	0.87 ± 0.03	2.96 ± 0.2	0.68 ± 0.6
(hours)	1	NA^*	0.5	NA
(M)	1.915 ± 0.03	2.11 ± 0.06	3.337 ± 0.2	0.96 ± 0.06
Vss (L/kg)	ND^*	9.51 ± 1	ND	27 ± 1.3
CL (mL/min/kg)	ND	83.6 ± 12	ND	92.6 ± 19
(M·min)	359.3 ± 97	103.4 ± 11	313.6 ± 30	105.1 ± 23
BA (%)	69 ± 19	NA	60 ± 5	NA

ND indicates that the value was not determined. NA: not applicable.