Nonobese Diabetic (NOD) Mice Lack a Protective B-Cell Response against the “Nonlethal” Plasmodium yoelii 17XNL Malaria Protozoan

Figure 1

Outcome of P. yoelii 17XNL infection in the NOD and C57BL/6 mice. (a) Parasitemia values in 10 NOD mice and 10 C57BL/6 mice after P. yoelii infection. The results were collected from two groups of each strain of mice (mice/group/strain) and represented together on the same graph. Of note, the complete clearance of P. yoelii parasites in C57BL/6 mice occurred by day 35 after infection. The degree of variability between the analyzed groups was null, since all NOD mice succumbed to the infection and all C57BL/6 mice self-cured the infection regardless of the time when the experiments were carried out. (b) The percentage of survival in NOD and C57BL/6 groups challenged with P. yoelii 17XNL sporozoites.

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