Nonobese Diabetic (NOD) Mice Lack a Protective B-Cell Response against the “Nonlethal” Plasmodium yoelii 17XNL Malaria Protozoan

Figure 3

Frequency of Foxp3⁺ CD4⁺ T regulatory cells (Tregs) in P. yoelii 17XNL-infected NOD mice. Cytofluorimetric analysis of Tregs was determined by FACS in the spleen cells from individual mice from both groups (mice/group) that were not infected or infected with P. yoelii 17XNL live sporozoites. FACS measurements were carried out 20 days after infection. (a) Percent of peripheral (splenic) Tregs in 3 individual mice from C57Bl/6 control mice () before and after each P. yoelii 17XNL challenge; group; (b) percent of peripheral (splenic) Tregs in the spleen of NOD mice () before and after P. yoelii 17XNL challenge. Shown are the significancevalues between the groups of infected and noninfected mice.

(a)

(b)