Long-Term Prophylaxis and Pharmacokinetic Evaluation of Intramuscular Nano- and Microparticle Decoquinate in Mice Infected with P. berghei Sporozoites

Table 3

Main pharmacokinetic parameters of decoquinate in oily suspension with nano- and microparticle following single intramuscular injection at 120 mg/kg dose level in mice liver ( = 2-3).

Main PK parameters following IM injection	Nano-DQ (0.43 µm); liver	CV%	Micro-DQ (8.31 µm); liver	CV%
(ng/g)	114.63 ± 7.19	6.27	455.29 ± 46.03	10.11
(hr)	3.36 ± 0.13	3.86	2.85 ± 0.39	13.68
(ng⋅hr/g)	127,674 ± 2,475	1.94	156,410 ± 15,076	9.64
(hr)	3.14 ± 0.27	8.59	1.98 ± 0.51	25.76
(hr)	861.16 ± 22.40	2.60	1,421.00 ± 40.26	2.83
MIC at 1,344 h (ng/ml)			47.35 ± 5.17	10.93

Value was calculated based on full causal prophylaxis effect for 8 weeks. IM: intramuscular; DQ: decoquinate.