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Multiple Sclerosis International
Volume 2011 (2011), Article ID 167156, 8 pages
http://dx.doi.org/10.1155/2011/167156
Research Article

Serum Metabolic Profile in Multiple Sclerosis Patients

1Institute of Biochemistry and Clinical Biochemistry, Catholic University of Rome, 00168 Rome, Italy
2Institute of Neurology, Catholic University of Rome, 00168 Rome, Italy
3Department of Biology, Geology and Environmental Sciences, Division of Biochemistry and Molecular Biology, University of Catania, 95125 Catania, Italy

Received 10 January 2011; Revised 30 March 2011; Accepted 2 May 2011

Academic Editor: Axel Petzold

Copyright © 2011 Barbara Tavazzi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Multiple sclerosis (MS) is a progressive demyelinating process considered as an autoimmune disease, although the causes of this pathology have not been yet fully established. Similarly to other neurodegenerations, MS is characterized by a series of biochemical changes affecting to different extent neuronal functions; great attention has been given to oxidative/nitrosative stress and to alterations in mitochondrial functions. According to previous data, MS patients show significant changes in the circulating concentrations of different metabolites, although it is still unclear whether uric acid undergoes to decrease, increase, or no change under this pathological condition. In this study, we report the serum metabolic profile in terms of purines, pyrimidines, creatinine, malondialdehyde, ascorbic acid, nitrite, and nitrate in a group of 170 MS patients. The results show increase in circulating uric acid and other oxypurines (hypoxanthine and xanthine), as well as in uridine and β-pseudouridine. The concomitant increase in circulating creatinine, malondialdehyde, nitrite, and nitrate, and decrease in ascorbic acid, demonstrates that MS induces alteration in energy metabolism and in oxidants/antioxidants balance that can be monitored in serum of MS patients.