Multiple Sclerosis International / 2011 / Article / Tab 1

Review Article

Consensus Guidelines for CSF and Blood Biobanking for CNS Biomarker Studies

Table 1

Results of inventory on collection protocols among 14 MS Biomarker Research Centers.

Procedure of CSF withdrawalPrevious status among European CSF centers

Type of needle:71% atraumatic, 21% traumatic, 8% both
Time of the day of withdrawal (important for markers that are sensitive for circadian rhythm)71% no specific day/time of withdrawal, 29% in the afternoon only
Temperature until storage57% room temperature, 43% at 4°C
Type of tube:50% Sarstedt, 29% Eppendorf, 21% other
aliquoting:Range from 0.2 mL to 2 mL
(1) surveillance of freezersPresent at 93% of the centers
(2) several freezers to split the samples (backup)Present at 14% of the centers

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