Research Article

Quantitative Magnetic Resonance Imaging of Cortical Multiple Sclerosis Pathology

Table 1

Mean (standard deviation) of the quantitative MR parameters and myelin content of four tissue types: normal appearing cortex (NAC), cortical lesions, normal appearing white matter (NAWM) and WM lesions. For all MR parameters and myelin content, -value < 0.0001 for differences between NAC and cortical lesions, and for differences between NAWM and WM lesions.

ā€‰NACCortical LesionNAWMWM Lesion

T1 time (ms)209 (27)236 (26)196 (18)380 (88)
T2 time (ms)64 (11)91 (22)56 (13)121 (27)
Proton density M0 (r.u.)3797 (114)3835 (86)3467 (88)4005 (111)
Magnetization transfer ratio MTR (%)7.47 (1.26)7.09 (1.09)12.82 (0.90)6.16 (2.79)
Myelin content (% area)7.96 (6.69)1.96 (2.55)74.18 (4.70)27.55 (14.32)