Research Article
Cortical Pathology in RRMS: Taking a Cue from Four Sisters
Table 2
Clinical and MRI characteristics of the studied populations.
| | | Familial cases () | Sporadic RRMS () | Healthy subjects () |
| | Age (years) | 46.5 ± 2.6 (43–49) | 46.5 ± 2.8 (42–49) | 46.5 ± 2.8 (41–50) | | Disease duration (years) | 4.0 ± 1.8 (2–6) | 4.1 ± 2.2 (1–8) | n.a. | | EDSS | 2.5 (1.0–3.0) | 2.5 (1.0–4.0) | n.a. | | WM lesions number | 11.7 ± 4.6 (6–16) | 11.4 ± 7.5 (4–28) | 0 | | T2WMLV (cm3) | 6.1 ± 4.2 (2.1–11.4) | 6.3 ± 5.8 (3.2–12.1) | 0 | | Patients with CEL | 0 | 4 (16%) | 0 | | Patients with SCL | 1 (25%) | 9 (36%) | 0 | | CLs number | 14.0 ± 2.9 (11–18)$ | 3.6 ± 3.6 (0–15) | 0 | | CL volume (mm3) | 1571 ± 376 (1225–2100)$ | 352 ± 602 (0–2975) | 0 | | Global CTh (mm) | 2.30 ± 0.05
(2.24–2.37)*$ | 2.38 ± 0.07
(2.22–2.59) | 2.47 ± 0.07
(2.12–2.69) |
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versus healthy subjects; $ versus sporadic RRMS.
EDSS: expanded disability status scale; T2WMLV: T2 white matter lesion volume; WM: white matter; CEL: contrast enhancing lesion; SCL: spinal cord lesions; CL: cortical lesion; CTh: cortical thickness.
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