Applying an Open-Source Segmentation Algorithm to Different OCT Devices in Multiple Sclerosis Patients and Healthy Controls: Implications for Clinical Trials

Table 5

Cross-sectional comparison of retinal layer thickness between HCs and MS subjects.

Layer	Difference in mean thickness (Spectralis) (μm)	value	Difference in mean thickness (Cirrus) (μm)	value
mRNFL	−3.54	0.001	−3.62	<0.001
GCIP	−9.47	<0.001	−9.04	<0.001
INL	−0.57	0.241	−0.31	0.498
INL + OPL	−0.87	0.321	−0.66	0.459
ONL	−2.58	0.087	−2.02	0.154
ONL + PR	−2.71	0.14	−2.44	0.172
RPE	−1.39	0.001	−0.92	0.131

Values adjusted for age and gender. mRNFL: macular retinal nerve fiber layer; GCIP: ganglion cell layer + inner plexiform layer; INL: inner nuclear layer; INL + OPL: inner nuclear layer + outer plexiform layer; ONL: outer nuclear layer; ONL + PR: outer nuclear layer + photoreceptor segments; RPE: retinal pigment epithelium.