Epidemiology of Neuromyelitis Optica in the World: A Systematic Review and Meta-Analysis

Table 3

Prevalence and incidence studies of Neuromyelitis optica.

Study (year)

Region (subgroup)

Design

Case ascertainment

Prevalence day/period

Diagnostic criteria (established by)

Population denominated

Number of patients

Female/male ratio

Mean age

Prevalence per 100,000; (95% CI)

Incidence per 100,000; (95% CI)

Quality score

Age of onset

Age of patients

Etemadifar et al. (2014) [9]

Isfahan

Population-based

Administrative database

10/10/2013

Wingerchuck

4880430

95

2.27 : 1

30

36.6

1.9 (1.6–2.3)

8/8

Pandit and Kundapur (2014) [13]

Mangalore

3 medical social workers

1-2011 to 6-2013

Wingerchuk

419,306

11

40 ± 18

2.6

5/8

Jacob et al. (2013) [10]

Merseyside

Administrative database

30/12/2010

Wingerchuk

1,145,322

13

3.5 : 1

0.72 (0.31–1.42)

0.08 (0.03–0.16)

8/8

Houzen et al. (2012) [14]

Tokachi

10 MS-related institutions

31/3/2011

Wingerchuk

352,353

3

0.9 (0.2–2.5)

8/8

Cossburn et al. (2012) [8]

South East Wales

Regional neurologist and hospitals & administrative database

01/05/2010

Wingerchuck

712,572

14

4.5 : 1

39.5

49

2 (1.22–2.97)

6/7

Asgari et al. (2011) [7]

Southern Denmark

Population-based

4 neurology and 3 ophthalmology departments

1/1/1998–31/12/2008

Wingerchuck

952,000

42

2.8

35.6

4.4 (3.1–5.7)

0.4 (0.3–0.54)

6/7

Cabrera-Gómez et al. (2009) [12]

Cuba

Neurologists, hospitals, administrative database

30/11/2004

Mayo Clinic

11,177,743

58

31.8

41.7

0.519 (0.394–0.671)

0.053 (0.040–0.068)

6/7

Cabre et al. (2009) [11]

French West Indies

Population-based

Neurologists, hospitals, administrative database

June 2007

Wingerchuck

1142857

48

9.8

30.9

39.8

4.2 (3.7–5.7)

0.20 (0.05–0.35)

6/7

Rivera et al. (2008) [15]

Mexico City

One tertiary care referral center

1993 to 2005

Mayo Clinic

18,400,000

34

1

2/8

Calculated from available data in the report.