Unless explicitly mentioned, no change is statistically significant. 1Mean IgG index is provided when available: elsewhere abnormal IgG indexes (>0.7) are provided as number or per cent of patients. 2OCB (IEF) are described as number or per cent of patients. Owing to subjectivity in counting, changes in mean OCB number are not taken into account. 3IT synthesis is assessed when > . Proportion of abnormal synthesis, IgGLoc, or mean changes of IgGLoc are reported. N/A: not assessed. Follow-up results without statistically significant changes are categorized as “unchanged.” Since our objective was an eventual normalization of intrathecal synthesis, we did not report synthesis fluctuations when they were not associated with at least normalization of results in some patients. For example, in , IgG synthesis rate decreased by 30% in 6 while increasing by 30% in 3 patients, but none achieved normal synthesis. *; **.