Research Article

Adipsin Is Associated with Multiple Sclerosis: A Follow-Up Study of Adipokines

Table 3

The levels of adipokines in MS subtypes and CIS over follow-up period (median (interquartile range)).

BaselineOne year Two years

Adiponectin (ng/mL)
CIS
RRMS
SPMS
PPMS
4720.6 (4124.4–5407.7) 
4517.3 (3380.6–6417.2)
4748.4 (3977.9–6379.9)
5618.7 (4111.5–8467.1)
5131.0 (4239.4–5880.3)
4695.7 (3452.4–7270.5)
5314.8 (4289.4–7494.9)
5855.8 (4622.6–9948.3)
5149.7 (4789.0–6812.0)
5012.7 (3222.8–7043.1)
6062.3 (4706.5–7871.2) 
5278.5 (3761.6–8779.1)

Adipsin (ng × m2/mL × kg)
CIS
RRMS
SPMS
PPMS
63.9 (53.9–76.8)
60.3 (52.3–71.2)
68.4 (57.4–85.0)
80.8 (69.5–93.6)
66.4 (56.9–83.5)
62.4 (55.1–71.3)
70.3 (63.3–81.7)
75.9 (67.1–94.6)
66.7 (59.7–74.4)
61.5 (56.2–69.6)
74.1 (57.7–89.6)
82.5 (66.1–95.0)

Leptin (pg × m2/mL × kg)
CIS
RRMS
SPMS
PPMS
861.0 (269.8–1908.4)
662.4 (288.1–981.4)
711.1 (166.8–1649.7)
515.2 (182.6–1260.2)
694.9 (240.1–1238.7)
572.4 (286.7–1159.3)
420.0 (157.5–1496.2)
603.3 (203.5–1092.2)
754.5 (424.2–1346.5)
572.0 (321.4–1032.9)
953.2 (287.9–1822.7)
479.3 (255.6–776.1)

Resistin (pg/mL)
CIS
RRMS
SPMS
PPMS
2851.5 (2509.1–3280.5)
2505.2 (2085.0–2751.0)
2605.4 (2216.0–3388.0)
2392.5 (1794.9–3411.5)
2946.6 (2367.6–3093.8)
2402.1 (2064.9–2869.3)
2649.9 (2358.5–3146.4)
2371.2 (1663.5–3354.6)
2769.5 (2299.2–3072.8)
2315.9 (1946.9–2796.2) 
2469.0 (2284.6–2975.3)
2445.4 (1711.1–3349.5)

BMI-adjusted adipsin levels (ng × m2/mL × kg).
BMI-adjusted leptin levels (pg × m2/mL × kg).
Comparison of PPMS .
#Comparison of PPMS after adjusting for age .