EDSS Change Relates to Physical HRQoL While Relapse Occurrence Relates to Overall HRQoL in Patients with Multiple Sclerosis Receiving Subcutaneous Interferon β-1a

Table 2

Mean values and paired changes from baseline in MSQOL-54 PCS and MCS and in EDSS scores.

Dimension	Baseline	12 months	24 months	Early termination
MSQOL-54 PCS
	313	238	182^a	68
Mean (SD)	60.9 (19.7)	65.0 (20.0)	64.9 (20.3)	60.7 (22.8)
Paired change from baseline
	—	230	174^a	66
Mean (SD)	—	2.0 (14.3)	2.2 (15.3)	0.3 (14.4)
value^b	—	0.014	0.027	NS
MSQOL-54 MCS
	331	249	191^a	73
Mean (SD)	65.6 (20.5)	71.4 (19.7)	71.7 (20.0)	67.3 (22.5)
Paired change from baseline
	—	248	190^a	72
Mean (SD)	—	3.7 (17.5)	4.3 (19.1)	1.3 (19.2)
value^b	—	<0.0001	0.0003	NS
EDSS score
	334	251	196	73
Mean (SD)	2.0 (1.4)	1.8 (1.3)	1.9 (1.4)	2.2 (1.8)
Paired change from baseline
	—	251	196	73
Mean (SD)	—	−0.1 (0.9)	0.1 (1.0)	0.1 (1.0)
value^b	—	0.047	NS	NS

MCS and PCS are expressed on a scale of 0 (poorest quality of life) to 100 (best possible quality of life). Paired changes from baseline to 24 months and ET in MSQOL-54 PCS and MCS and EDSS scores were also previously reported in Moore et al. [6].
numbers lower than 196 (number of patients who completed the 24-month study); data for these endpoints were not available for all patients who completed the study.
value calculated using a two-sided Wilcoxon matched pairs signed-rank test.
EDSS, Expanded Disability Status Scale; ET, early termination; MCS, mental health composite score; MSQOL-54, Multiple Sclerosis Quality of Life-54; NS, not statistically significant; PCS, physical health composite score; SD, standard deviation.