Free Light Chains and Intrathecal B Cells Activity in Multiple Sclerosis: A Prospective Study and Meta-Analysis

Table 3

Diagnostic accuracy of free light chain (a) and CSF standard indices (b) in multiple sclerosis (MS) and clinically isolated syndrome suggestive of MS diagnosis.

Markers	Cut-off point	Sensitivity	Specificity	Positive LR	Negative LR
KFLC (mg/l) in CSF	4.1	66.1	77.3	2.9	0.4
KFLC index	2.4	89.3	77.3	3.9	0.1
LFLC (mg/l) in CSF	4.3	55.4	72.7	2.0	0.6
LFLC index	3.0	82.1	75.0	3.3	0.2
Link index	0.6	53.6	93.2	7.9	0.5
Tourtellotte index	−0.9	60.7	75.0	2.4	0.5
Reiber IgG	−0.6	71.4	79.5	3.5	0.4
Qalb index	5.8	76.8	65.9	2.3	0.4

KFLC, kappa free light chain; LFLC, lambda free light chain; LR, likelihood ratio.