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Neuroscience Journal
Volume 2013, Article ID 424695, 9 pages
http://dx.doi.org/10.1155/2013/424695
Clinical Study

Significance of Haemodynamic and Haemostatic Factors in the Course of Different Manifestations of Cerebral Small Vessel Disease: The SHEF-CSVD Study—Study Rationale and Protocol

1Clinic of Neurology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland
2Department of Radiology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland
3Clinic of Ophthalmology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland
4Department of Laboratory Medicine, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland

Received 16 September 2012; Accepted 11 December 2012

Academic Editor: Atul Goel

Copyright © 2013 Jacek Staszewski et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Rationale. This paper describes the rationale and design of the SHEF-CSVD Study, which aims to determine the long-term clinical and radiological course of cerebral small vessel disease (CSVD) and to evaluate haemostatic and haemodynamic prognostic factors of the condition. Design. This single-centre, prospective, non-interventional cohort study will follow 150 consecutive patients with different clinical manifestations of CSVD (lacunar ischaemic stroke, vascular dementia, vascular parkinsonism or spontaneous deep, intracerebral haemorrhage) and 50 age- and sex-matched controls over a period of 24 months. The clinical and radiological course will be evaluated basing on a detailed neurological, neuropsychological and MRI examinations. Haemodynamic (cerebral vasoreactivity, 24 h blood pressure control) and haemostatic factors (markers of endothelial and platelet dysfunction, brachial artery flow-mediated dilatation test) will be determined. Discussion. The scheduled study will specifically address the issue of haemodynamic and haemostatic prognostic factors and their course over time in various clinical manifestations of CSVD. The findings may aid the development of prophylactic strategies and individualised treatment plans, which are critical during the early stages of the disease.