Clinical Study

Significance of Haemodynamic and Haemostatic Factors in the Course of Different Manifestations of Cerebral Small Vessel Disease: The SHEF-CSVD Study—Study Rationale and Protocol

Table 1

Diagnostic criteria for lacunar stroke, deep intracerebral haemorrhage, chronic vascular parkinsonism, and vascular dementia.

Lacunar strokeDeep intracerebral haemorrhageChronic vascular parkinsonismVascular dementiaPoints

(i) One of the recognised lacunar syndromes (unilateral motor/sensory signs involving the whole of at least 2 of the 3 bodyparts (face, arm, and leg)) (i) Spontaneous haemorrhage confirmed by CT scan in the thalamus, basal ganglia or pons, presumably due to CSVD(i) Subacute or acute onset (i) Abrupt onset2
(ii) No disturbances of consciousness or cortical functions(ii) Exclusion of other causes (e.g., trauma, altered hemostasis, haemorrhagic necrosis, cerebralvenous thrombosis, rupture of an aneurysm or arteriovenous malformation, other arteriopathies including cerebral amyloid angiopathy, moyamoya disease)(ii) Stepwise progression of symptoms(ii) Stepwise progression of symptoms1
(iii) a small hyperintense, sharply marginated subcortical lesion ≥3 mm <15 mm in diameter on T2-weighted MRI, which is compatible with the clinical findings listed above  (iii) Presence of vascular risk factors(iii) Fluctuating course of disorder2
(iv) Predominant signs of lower body parkinsonism(iv) Nocturnal confusion (sundowning)1
(v) Lack of significant clinical response to L-Dopa(v) Relative preservation of personality1
(vi) Typical radiological findings of CSVD(vi) Depression1
(vii) Somatic complaints1
(viii) Emotional lability1
(ix) History of hypertension1
(x) History of stroke2
(xi) Evidence of associated atherosclerosis1
(xii) Focal neurological symptoms2
(xiii) Focal neuroradiological findings2