The mGlu2/3 Receptor Agonists LY354740 and LY379268 Differentially Regulate Restraint-Stress-Induced Expression of c-Fos in Rat Cerebral Cortex

Figure 5

DOI produced an increase in c-Fos in the PrL (a) and IL (b) cortex. Pretreatment with LY354740 (3 and 10 mg/kg) attenuated the DOI-induced increase in the PrL and IL cortex. * indicates significantly different from vehicle; ***𝑃<0.001, ^# indicates significantly different from DOI; ^##𝑃<0.01, ^###𝑃<0.001. One-way ANOVA with Newman-Keuls post hoc test. Each bar represents the mean (±SEM), 𝑛=7-8.

(a)

(b)