Roles of Integrins and Intracellular Molecules in the Migration and Neuritogenesis of Fetal Cortical Neurons: MEK Regulates Only the Neuritogenesis
Figure 3
ECM effects on the migration of neurons. Neurons per field of Boyden membrane coated with laminin (a) or fibronectin (b). *Migration of cortical neurons were significantly () higher on membranes coated with laminin at 5, 10, 20, and 50 μM or 20 to 200 μM fibronectin compared to those coated with only Poly-D lysine (shaded bar). Migration of neurons was highest at 10 μM laminin but it was not significantly different than those at 20 μM laminin. Migration of neurons on fibronectin-coated membranes increased with concentration to reach its maximum at 100 μM that was not significantly () different than membranes coated with 200 μM fibronectin.
