Teratogenic Effect of Crude Ethanolic Root Bark and Leaf Extracts of Rauwolfia vomitoria (Apocynaceae) on Nissl Substances of Albino Wistar Rat Fetuses
Photomicrographs of the cerebral cortex of control and treated group whose mothers received 150 mg/kg root bark and leaf extracts (Cresyl fast violet ×400 for all plates). (a) Control cerebral cortex section showing normal staining of Nissl substance with many neurons in the intermediate zone (I) and few in cortical (C), subventricular (SV), and ventricular layers (V). (b) Fetal cerebral cortex—150 mg/kg of root bark extract showing fewer neurons with reduced staining of Nissl substance. (c) Fetal cerebral cortex—150 mg/kg of leaf extract showing slight reduction in the staining intensity of the Nissl substance especially in the cortical layer.