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Neuroscience Journal
Volume 2017, Article ID 9606213, 9 pages
https://doi.org/10.1155/2017/9606213
Research Article

Seizure Detection and Network Dynamics of Generalized Convulsive Seizures: Towards Rational Designing of Closed-Loop Neuromodulation

1Systems Science and Informatics Unit, Indian Statistical Institute, Kolkata, India
2Department of Clinical Neurosciences, NIMHANS, Bangalore 560029, India
3Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA

Correspondence should be addressed to Sandipan Pati; ude.cmbau@itaps

Received 11 August 2017; Revised 6 November 2017; Accepted 13 November 2017; Published 13 December 2017

Academic Editor: Fabio García-García

Copyright © 2017 Puneet Dheer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Studies have demonstrated the utility of closed-loop neuromodulation in treating focal onset seizures. There is an utmost need of neurostimulation therapy for generalized tonic-clonic seizures. The study goals are to map the thalamocortical network dynamics during the generalized convulsive seizures and identify targets for reliable seizure detection. Methods. Local field potentials were recorded from bilateral cortex, hippocampi, and centromedian thalami in Sprague-Dawley rats. Pentylenetetrazol was used to induce multiple convulsive seizures. The performances of two automated seizure detection methods (line length and P-operators) as a function of different cortical and subcortical structures were estimated. Multiple linear correlations-Granger’s Causality was used to determine the effective connectivity. Results. Of the 29 generalized tonic-clonic seizures analyzed, line length detected 100% of seizures in all the channels while the P-operator detected only 35% of seizures. The detection latencies were shortest in the thalamus in comparison to the cortex. There was a decrease in amplitude correlation within the thalamocortical network during the seizure, and flow of information was decreased from thalamus to hippocampal-parietal nodes. Significance. The preclinical study confirms thalamus as a superior target for automated detection of generalized seizures and modulation of synchrony to increase coupling may be a strategy to abate seizures.